环状RNA在糖尿病视网膜病变中的作用研究进展  

Research status and prospect of circular RNAs in diabetic retinopathy

作　　者：陆辰 邵珺 Lu Chen;Shao Jun(Department of Ophthalmology,Wuxi People’s Hospital of Nanjing Medical University,Wuxi 214023,China)

机构地区：[1]南京医科大学附属无锡人民医院眼科,无锡214023

出　　处：《中华眼底病杂志》2022年第1期77-80,共4页Chinese Journal of Ocular Fundus Diseases

基　　金：国家自然科学基金(81970819);无锡市双百拔尖人才(2020012);中国博士后67批面上项目(2020M671541)。

摘　　要：视网膜微血管功能失调、炎症反应过度激活以及神经元的退行性病变是糖尿病视网膜病变(DR)的主要发病机制。环状RNA(circRNA)是一类主要由前体RNA经剪切加工后具有特殊环状结构的内源性非编码RNA,其广泛存在于视网膜中并参与各种眼底疾病的发生发展。已有研究表明,circRNA在DR视网膜组织中存在异常表达,并且其可作为miRNA的"海绵",通过参与视网膜微血管功能失调、炎症反应及神经元退行性病变过程影响DR的发生发展。未来,对circRNA在DR中的探索将深入阐明DR的病理生理过程,使其有望成为DR诊断的生物标志物及治疗的分子靶点,从而实现DR早期诊断及精准治疗的目标。The mechanisms behind diabetic retinopathy(DR)can be ascribed primarily to retinal microvascular abnormalities,excessive inflammatory response and neurodegeneration.Circular RNA(circRNA)is a type of endogenous non-coding RNA with a special circular structure,which is mainly composed of precursor RNA after shearing and processing.It is widely present in the retina and participates in the occurrence and development of various fundus diseases.CircRNAs express in an abnormal way in retina,serving as"the sponge"for miRNA so as to play roles in dysfunction of retinal vascular,inflammatory response and neurodegeneration in the development of DR.Further studies for circRNAs in DR will illustrate pathophysiology of DR more deeply,shedding light on circRNAs becoming novel biomarkers and molecular targets for diagnosis and treatment,thus achieving the goal of early diagnosis and precise therapy of DR.

关 键 词：糖尿病视网膜病变 生物学标记 药理学 分子靶向治疗 综述 环状RNA 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]