赖氨肌醇维B_(12)联合莫沙必利治疗儿童功能性消化不良的效果分析  

Analysis on the Effect of Lysine Inositol Vitamin B_(12) Combined with Mosapride in the Treatment of Children with Functional Dyspepsia

作　　者：薛庆辉[1] 安玉凤 XUE Qinghui;AN Yufeng(3^(rd)Department of Pediatrics,Nanyang First People's Hospital,Nanyang 473000,China)

机构地区：[1]南阳市第一人民医院儿三科,河南南阳473000

出　　处：《临床医学工程》2022年第1期39-40,共2页Clinical Medicine & Engineering

基　　金：河南省医学科技攻关计划联合共建项目(项目编号:LHGJ20191500)。

摘　　要：目的探讨赖氨肌醇维B_(12)联合莫沙必利治疗儿童功能性消化不良(FD)的临床效果。方法选取2019年5月至2021年5月我院收治的88例FD患儿,随机分为两组各44例。对照组予以莫沙必利治疗,观察组在对照组基础上采用赖氨肌醇维B_(12)治疗。两组均持续用药2周。比较两组患儿的临床疗效、胃动力学指标及不良反应发生情况。结果观察组治疗总有效率为95.45%,明显高于对照组的81.82%(P<0.05)。治疗2周后,两组的胃半排空时间短于治疗前,胃窦收缩频率、胃窦收缩幅度高于治疗前,且观察组的胃半排空时间短于对照组,胃窦收缩频率、胃窦收缩幅度高于对照组(P<0.05)。治疗期间,两组患儿的不良反应发生率(6.82%vs. 4.55%)比较,差异无统计学意义(P>0.05)。结论赖氨肌醇维B_(12)联合莫沙必利治疗儿童FD效果显著,可有效改善其胃肠运动功能,且安全性较高,值得临床推广应用。Objective To explore the clinical effect of lysine inositol vitamin B_(12) combined with mosapride in the treatment of children with functional dyspepsia(FD).Methods 88 FD children admitted to our hospital from May 2019 to May 2021 were selected and randomly divided into two groups,with 44 cases in each group.The control group was treated with mosapride,and the observation group was treated with lysine inositol vitamin B_(12) on the basis of the control group.Both groups were treated for 2 weeks continuously.The clinical efficacy,gastric motility indicators and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.45%,significantly higher than 81.82%in the control group(P<0.05).After 2 weeks of treatment,the gastric half emptying time of the two groups were shorter than those before treatment,and the gastric antrum contraction frequency and amplitude were higher than those before treatment(P<0.05);The gastric half emptying time of the observation group was shorter than that of the control group,and the gastric antrum contraction frequency and amplitude were higher than those of the control group(P<0.05).During the treatment,no statistical difference was found in the incidence of adverse reactions(6.82%vs.4.55%)between the two groups(P>0.05).Conclusions Lysine inositol vitamin B_(12) combined with mosapride has significant effect in the treatment of FD children,and can effectively improve their gastrointestinal motility function with higher safety,which is worthy of clinical promotion and application.

关 键 词：功能性消化不良 赖氨肌醇维B_(12) 莫沙必利 胃动力学 不良反应 

分 类 号：R725.7[医药卫生—儿科]