谷氨酰胺联合早期肠内营养对急性重症胰腺炎全身炎症的影响评价临床研究  

Clinical Study on the Effect of Glutamine Combined with Early Enteral Nutrition on Systemic Inflammation in Severe Acute Pancreatitis

作　　者：孙瑜婧[1] SUN Yujing(Zhongshan Hospital Affiliated to Xiamen University,Xiamen,Fujian Province,361004 China)

机构地区：[1]厦门大学附属中山医院,福建厦门361004

出　　处：《中外医疗》2021年第35期120-122,126,共4页China & Foreign Medical Treatment

摘　　要：目的探究急性重症胰腺炎全身炎症患者选择谷氨酰胺联合早期肠内营养干预治疗的临床效果,并分析对患者炎症水平的影响。方法随机选取该院2019年2月—2021年4月收治的90例急性重症胰腺炎患者,基于抛硬币分组方式对研究对象进行等比例划分,每组45例,分别为常规组与联合组,常规组应用的治疗方式为全肠外营养干预,联合组应用的治疗方式为谷氨酰胺联合早期肠内营养干预,对两组患者的临床治疗效果、免疫功能指标与炎症因子水平进行对比。结果联合组临床治疗有效率(97.8%)与常规组比较,差异有统计学意义(χ^(2)=7.200,P=0.007);联合组患者CRP、TNF-α、IL-6、IgG、IgA、IgM数据分别为(1.42±0.39)mg/L、(7.24±1.25)pg/L、(5.20±1.01)pg/L、(11.74±1.84)g/L、(2.38±0.43)g/L、(1.65±0.47)g/L,与常规组对比,差异有统计学意义(t=9.698、19.320、6.428、4.678、4.528、3.578,P<0.05)。结论谷氨酰胺联合早期肠内营养的治疗方案具有显著的应用优势,能够改善患者炎症因子水平,可有效调节患者免疫功能,对患者的临床治疗具有重要价值。Objective To explore the clinical effects of glutamine combined with early enteral nutrition intervention in patients with severe acute pancreatitis and systemic inflammation,and to analyze the impact on the level of inflammation in patients.Methods 90 patients with severe acute pancreatitis treated in the hospital from February 2019 to April 2021 were randomly selected.The subjects were divided equally based on coin tossing grouping,with 45 cases in each group,including routine group and combined group,and the treatment method used in the routine group was total parenteral nutrition intervention,and the treatment method used in the combinen group was glutamine combined with early enteral nutrition intervention.The clinical treatment effect,immune function index and immune function index of the two groups of patients of inflammatory factors were compared.Results The effective rate of clinical treatment in the combined group(97.8%)compared with the routine group has obvious advantages,the difference was statistically significant(χ^(2)=7.200,P=0.007);the data of CRP,TNF-α,IL-6,IgG,IgA,IgM in the combined group were respectively(1.42±0.39)mg/L,(7.24±1.25)pg/L,(5.20±1.01)pg/L,(11.74±1.84)g/L,(2.38±0.43)g/L,(1.65±0.47)g/L,compared with the routine group,the difference was statistically significant(t=9.698,19.320,6.428,4.678,4.528,3.578,P<0.05).Conclusion The treatment of glutamine combined with early enteral nutrition has significant application advantages,can improve the level of inflammatory factors in patients,and can effectively regulate the immune function of patients.The clinical treatment of patients is of great value.

关 键 词：谷氨酰胺 早期肠内营养 急性重症胰腺炎 全身炎症 免疫功能 

分 类 号：R5[医药卫生—内科学]