母亲孕前BMI和孕期增重对0~1岁儿童BMI生长轨迹影响作用的研究  

A study of the effects of maternal pre-pregnancy BMI and gestational weight gain on BMI growth trajectory in infants aged 0 to 1 years

作　　者：刘宇辞 陶兴永[1] 黄锟[1] 严双琴 伍晓艳[1] 曹慧 陶芳标[1] LIU Yu-ci;TAO Xing-yong;HUANG Kun;YAN Shuang-qin;WU Xiao-yan;CAO Hui;TAO Fang-biao(Department of Maternal,Child and Adolescent Health,School of Public Health,Anhui Medical University,Hefei,Anhui 230032,China;不详)

机构地区：[1]安徽医科大学公共卫生学院儿少卫生与妇幼保健学系,出生人口健康教育部重点实验室,人口健康与优生安徽省重点实验室,安徽合肥230032 [2]安徽省马鞍山市妇幼保健院保健部

出　　处：《现代预防医学》2022年第2期246-249,262,共5页Modern Preventive Medicine

基　　金：国家自然科学基金项目资助(81573168);安徽高校自然科学研究重点项目(KJ2019A0941);安徽医科大学博士科研资助基金(XJ201704)。

摘　　要：目的描述0~1岁儿童BMI生长轨迹,并探讨母亲孕前BMI及孕期增重对其影响。方法研究对象源自马鞍山优生优育队列(MABC),该队列于2013年5月—2014年9月建立。本研究将符合条件的3 079名对象纳入分析,收集孕妇相关信息和新生儿出生时资料。并在婴儿出生后42天、3月龄、6月龄、9月龄、12月龄随访时收集其身长、体重、喂养情况等数据信息。运用潜变量增长模型拟合0~1岁儿童BMI生长轨迹,将不同的生长轨迹命名为特定的生长模式。采用多项式logistic回归模型分析孕前BMI和孕期增重与不同生长轨迹的关联。结果根据潜变量增长模型,可将3 079名儿童的发育轨迹划分为4类:较慢生长轨迹(n=463)、适宜生长轨迹(n=1 326)、较快生长轨迹(n=1 027)和持续高生长轨迹(n=263)。多因素logistic回归分析显示:母亲孕前肥胖/超重可预测儿童早期持续高生长模式的发生(OR=1.67,95%CI:1.16~2.41),母亲孕前肥胖/超重其子代呈现较慢生长模式的可能性更小(OR=0.64,95%CI:0.42~0.97),母亲孕前消瘦的儿童更易成为较慢生长模式(OR=1.60,95%CI:1.24~2.06);母亲孕期增重与儿童早期生长轨迹间关联均无显著性。结论 0~1岁婴儿BMI生长轨迹可分为较慢、适宜、较快和持续高值4种模式;母亲孕前BMI对0~1岁儿童生长模式有预测作用,孕期增重情况与0~1岁婴儿BMI生长模式无统计学关联。Objective To describe the BMI growth trajectory in infants aged 0 to 1 year and to explore the influence of maternal pre-pregnancy BMI and gestational weight gain on BMI growth trajectory.Methods The participants were from Ma’anshan Birth Cohort Study(MABC),which was established from May 2013 to September 2014.In this study,3 079 eligible participants were included,and the relevant information of pregnant women and the birth data of newborns were collected.The data of body length,weight and feeding were collected at 42 days,3 months,6 months,9 months,and 12 months,respectively.The latent class growth model was conducted to identify distinct BMI z-score trajectories of 0 to 1 year old in-fants,and the different growth trajectories were named as specific growth patterns.Multinomial logistic regression model was used for analyzing the relationship between pre-pregnancy BMI and gestational weight gain and distinct growth trajectories.Results According to the latent class growth model,the 3 079 infants showed four obvious growth trajectories:slow growth trajectory(n=463),normal growth trajectory(n=1 326),fast growth trajectory(n=1 027) and sustained high growth trajectory(n=263).Multinomial logistic regression analysis showed that pre-pregnancy overweight/obesity could predict the occurrence of sustained high growth pattern in infants(OR=1.67,95%CI:1.16-2.41),and the infants whose mothers were overweight/obesity before pregnancy were less likely to show a slow growth pattern(OR=0.64,95%CI:0.42-0.97),while infants whose mother had pre-pregnancy underweight were more likely to show a slow growth pattern(OR=1.60,95%CI:1.24-2.06).There was no significant correlation between gestational weight gain and infants ’ growth trajectory.Conclusion The BMI development trajectory of infants aged 0 to 1 year can be divided into four patterns:slow,normal,fast,and sustained high pattern.The pre-pregnancy BMI has a predictive effect on the growth pattern of infants,while the weight gain during pregnancy has no statistical correlati

关 键 词：儿童生长轨迹 孕前体质指数 孕期增重 队列研究 

分 类 号：R174[医药卫生—妇幼卫生保健]