滕州市2018—2020年HPV疫苗接种及影响因素配对病例对照研究  

Vaccination prevalence and influencing factors of HPV vaccine among women in Tengzhou city,2018–2020:a paired case-control study

作　　者：袁克兵 张培英 杨猛 张帅 YUAN Ke-bing;ZHANG Pei-ying;YANG Meng(Tengzhou Municipal Center for Disease Control and Prevention,Tengzhou,Shandong Province 277599,China;不详)

机构地区：[1]滕州市疾病预防控制中心免疫规划科,山东277599 [2]滕州市中心人民医院

出　　处：《中国公共卫生》2021年第12期1746-1750,共5页Chinese Journal of Public Health

摘　　要：目的了解山东省滕州市人乳头瘤病毒(HPV)疫苗接种现状,探讨影响因素,为制定HPV疫苗宣传及推广策略提供参考。方法选取HPV疫苗全程合格接种者作为研究组,按照研究组与对照1:1配对设计,同时选取未接种HPV疫苗的女性人群并经知情同意后作为对照,采用条件logistic回归模型对HPV疫苗接种影响因素进行多因素分析。结果2018—2020年女性HPV疫苗年均接种率为0.28%,城区(0.67%)显著高于农村(0.13%)(χ^(2)=3261.74,P<0.01),30~34岁接种率最高,为0.54%,9~14岁最低,为0.1%,不同年龄接种率差异显著(χ^(2)=1703.87,P<0.01)。多因素条件logistic回归分析结果表明,在婚状态、文化水平和经济收入高、有肿瘤家族史、知晓HPV病原体、相信HPV疫苗6种因素是提高女性HPV疫苗接种的有利因素(均P<0.05)。结论滕州市女性适龄人群HPV接种率低于国内资料报道,可结合女性HPV疫苗接种的影响因素,制定宣传及推广女性HPV疫苗。Objective To examine current situation and influencing factors of human papillomavirus(HPV)vaccine vaccination among women in Tengzhou city,Shandong province and to provide references for developing strategies on promotion of HPV vaccine vaccination.Methods The study included an analysis on registry data of HPV vaccination among residents in Tengzhou city during 2018-2020 and a case-control survey.The cases were 268 women HPVvaccinated in the three-year period and selected with cluster random sampling in the city;the controls were 1:1 gender-,age(±three years)-,and living residence(village/community)-matched un-vaccinated women without contraindications for HPV vaccination.Face-to-face household interviews were carried out among the participants using a self-desinged questionnaire.Conditional logistic regression model was adopted to explore influencing factors of HPV vaccination.Results The average annual coverage rate of HPV vaccination among the women of the city was 0.28%during the period,with a significant higher vaccination rate(0.67%)among the women in urban regions than that(0.13%)among those in rural areas(χ^(2)=3261.74,P<0.01)and a significant higher rate(0.54%)among the women aged 30-34 years than that(0.1%)among those aged 9-14 years(χ^(2)=1703.87,P<0.01).Multivariate logistic regression analysis revealed six significant promoting factors for HPV vaccination as following:married,with the education of collage and above,with an annual personal income of 40000 yuan RMB and more,having family history of tumor,having knowledge about HPV infection,and believing in the effect of HPV vaccine(P<0.05 for all).Conclusion The HPV vaccination rate among appropriate age women in Tengzhou city was lower than that among those surveyed in other regions in China and the study results suggest that associated factors should be concerned for promoting HPV vaccination among the women.

关 键 词：宫颈癌 人乳头瘤病毒(HPV)疫苗 接种率 影响因素 病例对照 条件LOGISTIC回归 

分 类 号：R181[医药卫生—流行病学] R737.3[医药卫生—公共卫生与预防医学]