腹部脂肪分布与肺通气功能的关系研究  

Relationship between abdominal fat distribution and pulmonary ventilation function

作　　者：黄露[1] 王哲涛 罗凤鸣[1] HUANG Lu;WANG Zhetao;LUO Fengming(Department of Respiratory and Critical Care Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China;Department of Radiology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China)

机构地区：[1]四川大学华西医院呼吸与危重症医学科,成都610041 [2]四川大学华西医院放射科,成都610041

出　　处：《华西医学》2022年第1期27-32,共6页West China Medical Journal

摘　　要：目的研究内脏脂肪面积(visceral adipose tissue area,VTA)和皮下脂肪面积(subcutaneous adipose tissue area,STA)对肺通气功能的影响,进而评估腹部脂肪分布在肺通气功能中的作用。方法在四川大学华西医院的电子病历系统中选择2017年1月1日—12月31日既进行肺通气功能检查又完成腹部CT的患者。收集患者的人口学资料、肺通气功能指标[肺活量(vital capacity,VC)、用力肺活量(forced vital capacity,FVC)、1 s用力呼气容积(forced expiratory volume in one second,FEV_(1))、1 s率(FEV_(1)/FVC)],并通过腹部CT测量获得VTA和STA数据。比较患者肺通气功能与VTA和STA的相关性。结果共纳入患者224例。根据VTA/STA比值分组,其中VTA/STA<1组92例(41.07%),VTA/STA≥1组132例(58.93%)。VTA与FVC不相关(r_(s)=-0.078,P=0.244),与VC(r_(s)=-0.138,P=0.040)、FEV_(1)(r_(s)=-0.141,P=0.034)、FEV_(1)/FVC(r_(s)=-0.137,P=0.041)均呈负相关;STA则与VC、FVC、FEV_(1)、FEV_(1)/FVC均不相关(P>0.05)。VTA/STA与VC(r_(s)=-0.220,P=0.001)、FEV_(1)(r_(s)=-0.273,P<0.001)、FEV_(1)/FVC(r_(s)=-0.380,P<0.001)均呈负相关,与FVC不相关(r_(s)=-0.083,P=0.214)。在VTA/STA<1组,VTA/STA与FEV_(1)(r_(s)=-0.205,P=0.050)、FEV_(1)/FVC(r_(s)=-0.317,P=0.002)呈负相关,与VC、FVC均不相关(P>0.05);在VTA/STA≥1组,VTA/STA与VC、FVC、FEV_(1)、FEV_(1)/FVC均呈负相关(P<0.05)。结论VTA和STA与肺通气功能多呈负相关,VTA/STA可以作为评估腹部脂肪分布与肺通气功能之间关系的一个指标。Objective To study the effects of visceral adipose tissue area(VTA)and subcutaneous adipose tissue area(STA)on pulmonary ventilation function(PVF),and then to evaluate the impact of abdominal fat distribution on PVF.Methods Patients who underwent both PVF examination and abdominal CT between January 1 st and December31 st,2017 were selected from the electronic medical record system of West China Hospital of Sichuan University.The demographic data and PVF indexes[vital capacity(VC),forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1)),and 1 s rate(FEV_(1)/FVC)]were collected.VTA and STA were obtained by abdominal CT measurement.The correlations between PVF indexes and VTA or STA were compared.Results A total of 224 patients were included.According to the VTA/STA ratio,there were 92 cases(41.07%)in group VTA/STA<1 and 132 cases(58.93%)in group VTA/STA≥1.VTA was not correlated with FVC(r_(s)=-0.078,P=0.244),but negatively correlated with VC(r_(s)=-0.138,P=0.040),FEV_(1)(r_(s)=-0.141,P=0.034)and FEV_(1)/FVC(r_(s)=-0.137,P=0.041);STA had no correlation with VC,FVC,FEV_(1) or FEV_(1)/FVC(P>0.05).VTA/STA was negatively correlated with VC(r_(s)=-0.220,P=0.001),FEV_(1)(r_(s)=-0.273,P<0.001)and FEV_(1)/FVC(r_(s)=-0.380,P<0.001),but it had no correlation with FVC(r_(s)=-0.083,P=0.214).In group VTA/STA<1,VTA/STA was negatively correlated with FEV_(1)(r_(s)=-0.205,P=0.050)and FEV_(1)/FVC(r_(s)=-0.317,P=0.002),but it had no correlation with VC or FVC(P>0.05).In group VTA/STA≥1,VTA/STA was negatively correlated with VC,FVC,FEV_(1) and FEV_(1)/FVC(P<0.05).Conclusions VTA and STA are negatively correlated with PVF.The ratio of VTA/STA can be used as an index to evaluate the effect of abdominal fat distribution on lung function.

关 键 词：内脏脂肪面积 皮下脂肪面积 肺通气功能 相关性分析 

分 类 号：R563[医药卫生—呼吸系统]