肥厚型心肌病患者血栓栓塞事件发病特点分析  

Analysis of the characteristics of thromboembolic events in patients with hypertrophic cardiomyopathy

作　　者：鄢晓龙 何森[1] 陈晓平[1] YAN Xiaolong;HE Sen;CHEN Xiaoping(Cardiac Cath Lab,West China Hospital,Sichuan University,Chengdu 610041,P.R.China;Department of Radiology,West China Hospital,Sichuan University,Chengdu 610041,P.R.China)

机构地区：[1]四川大学华西医院心内科导管室,成都610041 [2]四川大学华西医院放射科,成都610041

出　　处：《中国循证医学杂志》2022年第1期31-36,共6页Chinese Journal of Evidence-based Medicine

基　　金：国家自然科学基金项目(编号:81600299);四川省重点研发计划项目(编号:22ZDYF1527)。

摘　　要：目的分析肥厚型心肌病(HCM)患者血栓栓塞(TE)事件的特点。方法回顾性分析四川大学华西医院就诊HCM患者TE事件的发病特点。复合性TE事件包括:缺血性脑卒中、短暂性脑缺血性发作及外周动脉栓塞。结果共纳入537例HCM患者,中位随访时间为4.2年。随访过程中有42例首次发生TE事件,年发病率为1.9%。其中HCM患者未合并心房颤动,TE事件的年发病率为1.1%;合并心房颤动,年发病率为6.6%。患者发生首次TE事件后,再发事件率较高(26.2%)。患者发生首次TE事件的平均年龄为66.4±13.7岁;≥70岁时,TE事件发生率明显升高。结论HCM患者的TE事件发病率较高,特别是合并心房颤动的患者,且TE事件的再发率较高。Objective To analyze the clinical characteristics of thrombo embolism(TE)in Chinese hypertrophic cardiomyopathy(HCM)patients.Methods This study retrospectively analyzed HCM patients admitted to West China Hospital of Sichuan University.The endpoints were defined as a composite of TE events,including ischemic stroke,transient ischemic attack,and peripheral arterial embolization.Results A total of 537 HCM patients were included with a median follow-up of 4.2 years.Forty-two patients reached the TE endpoint and the incidence was 1.9%.The annual incidence of TE was approximately 1.1%and 6.6%for HCM patients without/with atrial fibrillation,respectively.The recurrence rate of TE was high(approximately 26.2%).The mean age was 66.4±13.7 years for the first TE,and the incidence of TE was significantly increased at age≥70 years.Conclusion The incidence of TE is high in HCM patients,especially in those with atrial fibrillation,and the recurrence rate of TE is also high.

关 键 词：肥厚型心肌病 血栓栓塞 临床特征 中国人群 

分 类 号：R542.2[医药卫生—心血管疾病]