噬菌体展示技术在新型冠状病毒肺炎诊治中的应用  

Application of phage display technology in detection and treatment of COVID-19

作　　者：陶雪蓉 曹东慧[1] 黄园园[2] 姜晶[1] Tao Xuerong;Cao Donghui;Huang Yuanyuan;Jiang Jing(Division of Clinical Research,First Hospital of Jilin University,Changchun 130021,China;Pediatric Department,First Hospital of Jilin University,Changchun 130021)

机构地区：[1]吉林大学第一医院临床研究部,长春130021 [2]吉林大学第一医院儿科门诊部,长春130021

出　　处：《国际流行病学传染病学杂志》2021年第6期489-493,共5页International Journal of Epidemiology and Infectious Disease

基　　金：吉林省科技发展计划重点研发项目(20200901026SF);吉林省教育厅重点项目(JJKH20211153KJ)。

摘　　要：新型冠状病毒肺炎在全球范围内广泛传播,对公众健康构成严重威胁。快速有效的检测手段对疫情监测与控制具有重要的意义。噬菌体抗体库是基于噬菌体展示技术发展起来的抗体文库,包含数以亿计的抗体变体,能够筛选出高特异性、高亲和力的抗体,已在多个领域中得到广泛应用,对于开发抗原检测试剂以及抗体治疗药物具有重要意义。本文对噬菌体展示技术及其在新型冠状病毒(SARS-CoV-2)检测与新型冠状病毒肺炎防治中的研究进展进行综述,为开发新型试剂、优化检测方法提供参考。COVID-19 has spread to the whole world and been a serious threat to public health.It is significant for epidemic surveillance and control by using rapid and effective detection methods.Phage antibody library based on phage display technology contains billions of antibody variants.Antibodies with high specificity and high affinity can be screened from the phage antibody library and have been widely applied in many fields.It is significant to develop antigen detection reagents and antibody therapeutic drugs.The phage display technology and its research progress in detection of SARS-CoV-2 and prevention and treatment of COVID-19 are reviewed in this article,so as to provide references for developing new reagents and optimizing detection methods.

关 键 词：SARS-CoV-2 噬菌体展示技术 抗体 检测 疫苗 

分 类 号：R563.1[医药卫生—呼吸系统]