Roles of interleukins in antibacterial immune defense of the brood pouch in the lined seahorse Hippocampus erectus  

作　　者：Han JIANG Chunyan LI Bo ZHANG Yongli WU Qiang LIN 

机构地区：[1]CAS Key Laboratory of Tropical Marine Bio-resources and Ecology,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China [2]Guangdong Provincial Key Laboratory of Applied Marine Biology,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Journal of Oceanology and Limnology》2022年第1期235-244,共10页海洋湖沼学报（英文）

基　　金：Supported by the National Science&Technology Fundamental Resources Investigation Program of China(No.2018FY100106),the National Natural Science Foundation of China(Nos.41825013,41806189);the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(No.GML2019ZD0407);the K.C.Wong Education Foundation,and the Guangdong Special Support Program of Leading Scientifi c and Technological Innovation(No.2017TX04N442)。

摘　　要：Seahorse embryos are brooded in the enclosed nutrient-rich environment of the male brood pouch,which may be prone to bacterial infection.The immune responses of interleukin(IL)genes in the brood pouch have not been well studied.We identifi ed 13 interleukins in the lined seahorse Hippocampus erectus.Tissue-specifi c expression analysis revealed increased mRNA expression levels of il-1β,il-18,and il-8 in the brood pouch.When challenged with lipopolysaccharide or Vibrio parahaemolyticus,il-1βand il-18 were active as part of the acute and chronic infl ammatory responses,respectively.Importantly,il-8 may be involved in powerful antibacterial immune responses and may be induced by il-1βand il-18 via a process involving the nuclear factor-κB signaling pathway.These results suggest that il-1β,il-18,and il-8 may play key roles in the antibacterial immune defense of the brood pouch in male seahorses.

关 键 词：lined seahorse brood pouch INTERLEUKIN antibacterial immunity 

分 类 号：Q939.91[生物学—微生物学]