不孕症患者血清激素及免疫抗体表达特点及其诊断价值  

Characteristics and Diagnostic Value of Serum Hormones and Immune Antibodies Expression in Infertile Patients

作　　者：江俏 邱瑾[1] 曾超帆 庞路勤 JIANG Qiao;QIU Jin;ZENG Chao-fan;PANG Lu-qin(Zhanjiang Central People's Hospital,Guangdong Zhanjiang 524000)

机构地区：[1]湛江中心人民医院,广东湛江524000

出　　处：《深圳中西医结合杂志》2021年第20期104-106,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨不孕症女性的血清激素水平及免疫抗体表达特点及临床诊疗情况。方法:选取2018年9月至2020年2月湛江中心人民医院收治的110例不孕症女性,依据月经期是否正常分为月经正常组(35例)、月经失调组(75例),同时选取同时期55名健康女性,将其作为对照组。分别对其进行血清激素及免疫抗体表达水平进行检测,对三组女性的血清免疫抗体表达阳性率、血清激素水平情况及不同不孕症类型的血清免疫抗体表达阳性率、血清激素水平进行比较。结果:月经正常组、月经失调组女性的血清免疫抗体表达阳性率明显高于对照组,差异具有统计学意义(P<0.05),但月经正常组、月经失调组女性的血清免疫抗体表达阳性率差异无统计学意义(P>0.05)。三组女性的孕酮(P)、雌二醇(E2)水平比较,差异无统计学意义(P>0.05);月经失调组女性促黄体生成激素(LH)、卵泡刺激素(FSH)水平均明显高于对照组与月经正常组,差异具有统计学意义(P<0.05);月经正常组与对照组的LH与FSH水平比较,差异无统计学意义(P>0.05)。原发性不孕症及习惯性流产患者血清抗精子抗体(AsAb)阳性率明显高于继发性不孕症患者与习惯性流产患者;习惯性流产患者血清抗子宫内膜抗体(AemAb)阳性率明显高于原发性不孕症及继发性不孕症患者,继发性不孕症及习惯性流产患者血清抗绒毛膜促性腺激素抗体(AhCGAb)阳性率明显低于原发性不孕症患者与习惯性流产患者;继发性不孕症患者血清抗心磷脂抗体(AcAb)阳性率明显低于原发性不孕症及习惯性流产患者,习惯性流产组的抗卵巢抗体(AoAb)阳性率明显低于原发性不孕症及继发性不孕症患者,差异均具有统计学意义(P<0.05)。三种不孕症类型患者的LH与FSH水平比较,差异均无统计学意义(P>0.05)。结论:血清激素及免疫抗体检测对于诊断不孕症具有良好的效果。Objective To investigate the expression characteristics of serum hormones and immune antibodies in women with infertility,as well as clinical diagnosis and treatment.Methods Select 110 infertile women admitted to Zhanjiang Central People’s Hospital from September 2018 to February 2020,were divided into a normal menstrual group (35 cases) and a menstrual disorder group (75 cases) according to whether their menstrual period was normal.During the same period,55 healthy women were treated as the control group.The expression levels of serum hormones and immune antibodies were detected respectively,and the positive rate of serum immune antibody expression,serum hormone levels and the positive rate of serum immune antibody expression and serum hormone levels of different types of infertility were compared.Results The positive rate of serum immune antibody expression of women in the normal menstrual group and menstrual disorder group was significantly higher than that of the control group,the difference was statistically significant (P < 0.05),but the positive rate of serum immune antibody expression in women in the normal menstrual group and menstrual disorder group,the difference was not statistically significant (P > 0.05).There was no statistically significant difference in the levels of progesterone (P) and estradiol (E2) among the three groups of women (P > 0.05);the levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in women in the menstrual disorder group it was significantly higher than that of the control group and the normal menstrual group,the difference was statistically significant(P < 0.05).There was no statistically significant difference between the LH and FSH levels of the normal menstrual group and the control group (P > 0.05).The positive rate of serum anti-sperm antibody (AsAb) in patients with primary infertility and habitual abortion was significantly higher than that in patients with secondary infertility and habitual abortion;the positive rate of serum anti-endometrial an

关 键 词：不孕症 血清激素 免疫抗体 女性 

分 类 号：R711.6[医药卫生—妇产科学]