nCPAP联合PS治疗新生儿呼吸窘迫综合征的疗效  

Effect of nCPAP Combined With PS in the Treatment of Neonatal Respiratory Distress Syndrome

作　　者：贾伟[1] 叶永康[1] JIA Wei;YE Yong-kang(Hanshou County People's Hospital,Hunan Hanshou 415900)

机构地区：[1]汉寿县人民医院,湖南汉寿415900

出　　处：《深圳中西医结合杂志》2021年第20期156-158,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:分析经鼻持续正压通气(nCPAP)联合肺表面活性物质(PS)治疗新生儿呼吸窘迫综合征的疗效及预后。方法:选取汉寿县人民医院2018年11月至2020年4月期间收治的36例新生儿呼吸窘迫综合征患儿,采用随机数字表法分为对照组与观察组,各18例。对照组患儿单独采用insure技术和PS治疗,观察组患儿使用insure技术并采用nCPAP联合PS治疗,并比较两组患儿进行治疗后的血气分析指标、临床指标以及并发症发生情况。结果:治疗前两组患儿的血气指标比较,差异无统计学意义(P>0.05);治疗后观察组患者的血氧分压(PaO_(2))、氢离子浓度指数(pH)高于对照组,血二氧化碳分压(PaCO_(2))低于对照组,差异具有统计学意义(P<0.05)。观察组患儿的氧疗时间、住院时间均短于对照组,差异具有统计学意义(P<0.05)。观察组患儿并发症发生率为6.25 %,低于对照组的20.83 %,差异具有统计学意义(P<0.05)。结论:在对新生儿呼吸窘迫综合征患儿进行治疗时,采用nCPAP联合PS治疗能够优化患儿血气分析指标,缩短患儿氧疗时间和住院时间,降低并发症的发生率。Objective To analyze the efficacy and prognosis of nasal continuous positive pressure ventilation (nCPAP) combined with pulmonary surfactant (PS) in the treatment of neonatal respiratory distress syndrome.Methods A total of 36 infants with neonatal respiratory distress syndrome admitted to Hanshou County People’s Hospital from November 2018 to April 2020 were selected and divided into control group and observation group by random number table method,with 18 cases in each group.Children in the control group were treated with insure technology and PS alone,and children in the observation group were treated with insure technology and received nCPAP combined with PS treatment.The blood gas analysis indexes of the two groups of children after treatment were compared,Clinical indicators and complications.Results There was no statistically significant difference in blood gas indexes between the two groups of children before treatment (P > 0.05).After treatment,the blood gas indexes of the observation group were better than those of the control group,and the difference was statistically significant (P < 0.05);After treatment,blood partial pressure of oxygen (PaO_(2)) and concentration of hydrogen ion (pH) in observation group were higher than those in control group,and blood partial pressure of carbon dioxide (PaCO_(2)) were lower than those in control group,and the difference was statistically significant (P < 0.05);the incidence of complications in the observation group was 6.25 %,which was lower than 20.83% in the control group,and the difference was statistically significant (P < 0.05).Conclusion In the treatment of children with neonatal respiratory distress syndrome,nCPAP combined with PS therapy can optimize the blood gas analysis indexes of the children,shorten the patient’s oxygen therapy time and hospital stay,and reduce the occurrence of complications.

关 键 词：新生儿呼吸窘迫综合征 经鼻持续正压通气 肺表面活性物质 

分 类 号：R722.1[医药卫生—儿科]