外泌体促进糖尿病溃疡创面愈合的meta分析  

Meta analysis of exosomes promoting healing of diabetic ulcer wound

作　　者：苏欢 简华刚[1] SU Huan;JIAN Huagang(Department of Emergency Surgery,Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属第二医院急诊外科,400010

出　　处：《重庆医学》2022年第2期307-312,319,共7页Chongqing medicine

摘　　要：目的系统评价外泌体促进糖尿病溃疡创面愈合的效果。方法检索PubMed、EMbase、The Cochrane Library、知网、CBM、万方、维普等数据库,检索时间为建库至2021年2月。使用系统分析软件RevMan 5.3对纳入文献进行meta分析。结果最终纳入10篇随机对照研究(RCTs),纳入研究的实验动物样本量共207只。Meta分析结果显示,实验组在糖尿病溃疡创面愈合的第7天(SMD=8.33,95%CI:5.58~11.09,P<0.001)、第14天(SMD=3.97,95%CI:2.44~5.40,P<0.001)创面愈合率高于对照组;实验组在创面愈合过程中创伤部位新生血管密度(SMD=7.60,95%CI:4.96~10.24,P<0.001)、胶原纤维沉积百分比(SMD=6.98,95%CI:1.41~12.56,P=0.010)、再上皮化程度(SMD=16.81,95%CI:1.81~31.80,P=0.030)高于对照组,瘢痕形成低于对照组(SMD=-3.41,95%CI:-5.21~-1.60,P<0.001)。结论外泌体应用于糖尿病溃疡,可以促进创面新生血管产生、改善上皮化及胶原纤维沉积,明显促进创面愈合,并减少瘢痕形成。Objective To systematically evaluate the effect of exosomes in promoting diabetic ulcer wound healing.Methods The databases of PubMed,Embase,Cochrane Library,CNKI,CBM,Wanfang and Vip were retrieved from their establishment to February 2021.The meta analysis was performed on the included literatures by using RevMan 5.3.Results Ten randomized controlled trials(RCTs)were finally included,with a total sample size of 207 cases.The meta analysis results showed that the wound healing rates on 7,14 d in the experimental group were higher than those in the control group(SMD=8.33,95%CI=5.58-11.09,P<0.001;SMD=3.97,95%CI=2.44-5.40,P<0.001).In the experimental group,the density of neovascularization(SMD=7.60,95%CI=4.96-10.24,P<0.001),percentage of collagen fiber deposition(SMD=6.98,95%CI=1.41-12.56,P=0.010),degree of re-epithelialization(SMD=16.81,95%CI=1.81-31.80,P=0.030)at the wound site were higher than those of the control group,and the scar formation was lower than that in the control group(SMD=-3.41,95%CI=-5.21--1.60,P<0.001).Conclusion The application of exosomes in diabetic ulcers can promote the generation of new blood vessels,improve epithelization and collagen fiber deposition at the wound site,significantly accelerate the wound healing,and reduce the scar formation.

关 键 词：外泌体 糖尿病性溃疡 创面愈合 META分析 

分 类 号：R632.1[医药卫生—外科学]