利水强心方改善慢性心力衰竭患者心功能的临床研究  

Clinical study of Lishui Qiangxin Recipe on improving heart function in patients with chronic heart failure

作　　者：陈兴娟 陈韵卓 胡影 吴怡茹 冯玲[1] CHEN Xingjuan;CHEN Yunzhuo;HU Ying;WU Yiru;FENG Ling(Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学,北京100029

出　　处：《中国临床医生杂志》2022年第2期148-150,共3页Chinese Journal For Clinicians

基　　金：国家自然基金面上项目(81774128)。

摘　　要：目的观察利水强心方对慢性心力衰竭患者的心功能改善疗效及安全性。方法选取2015年9月至2018年1月在中国中医科学院广安门医院收治的慢性心力衰竭患者60例,采用随机数字表法分为治疗组和对照组各30例,对照组给予西药基础治疗,治疗组在西药基础治疗上加用利水强心方颗粒剂,两组疗程均为8周。观察两组治疗前后的中医证候积分、左心室射血分数、6分钟步行试验、血浆脑钠肽前体水平及安全性指标。结果治疗后两组间中医证候积分、6分钟步行距离比较(P<0.05),左心室射血分数、血浆脑钠肽前体水平比较(P<0.01),差异有显著性。结论利水强心方可进一步改善心力衰竭患者的临床症状,提高左心室射血分数,降低血浆脑钠肽前体水平,具有良好的安全性及有效性。Objective To observe the efficacy and safety of Lishui Qiangxin Recipe in improving heart function in patients with chronic heart failure.Method Patients with chronic heart failure in Guang’anmen Hospital of Chinese Academy of traditional Chinese medicine from September 2015 to January 2018 were randomly divided into control group and treatment group,and 30 cases in each group were finally included in the analysis.The control group was given basic Western medicine treatment,while the treatment group was given basic Western medicine treatment plus Lishui Qiangxin Recipe.The course of treatment in both groups was 8 weeks.Result After treatment of the two groups,the differences in TCM syndrome scores,left ventricular ejection fraction,6 minutes walking distance,and plasma NT-proBNP levels were statistically significant(P<0.05).Conclusion Lishui Qiangxin Decoction could further improve the clinical symptoms of patients with heart failure,increase the left ventricular ejection fraction,and reduce the level of plasma NT-proBNP.It had good safety and effectiveness.

关 键 词：利水强心方 慢性心力衰竭 射血分数 血浆脑钠肽前体 6分钟步行距离 

分 类 号：R541[医药卫生—心血管疾病]