蒙古族瘦素受体、脂联素受体基因多态性与2型糖尿病交互作用研究  

Study on the interaction of leptin receptor and adiponectin receptor gene polymorphisms with type 2 diabetes in Mongolian population

作　　者：邬倩 高玉敏 李乌云塔娜[1,2] 庞慧 赵燕平 蔚培尧[1] 王志迪 陈乐 赵灵燕 WU Qian;GAO Yumin;LI Wuyuntana;PANG Hui;ZHAO Yanping;YU Peiyao;WANG Zhidi;CHEN Le;ZHAO Lingyan(Inner Mongolian Medical University,School of Public Health,Hohhot 010110,China;不详)

机构地区：[1]内蒙古医科大学公共卫生学院,呼和浩特010110 [2]内蒙古医科大学,慢性病分子流行病学重点实验室,呼和浩特010110 [3]内蒙古医科大学附属医院,呼和浩特010110

出　　处：《实用医学杂志》2022年第1期57-61,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:81660564);内蒙古医科大学慢性病分子流行病学创新团队(编号:YDK2017KJCXTD015);内蒙古医科大学“致远”人才计划(编号:ZY0201013);2020年度内蒙古自治区“草原英才”工程青年创新创业培养计划。

摘　　要：目的探究瘦素受体(LEPR)基因rs3790433与rs12037879、脂联素受体(ADIPOR1)基因rs10920533和ADIPOR2基因rs11061971位点多态性与环境因素交互作用对蒙古族2型糖尿病的影响。方法采用病例-对照方法,病例组来自呼和浩特市、锡林浩特市和通辽市的238例蒙古族2型糖尿病患者,对照组为238例同期健康蒙古族人群。多重高温连接酶检测反应检测基因位点多态性,广义多因素降维法(GMDR)分析基因多态性与环境因素的交互作用。结果rs3790433位点CC+CT基因型、rs1106197位点AA+AT基因型为蒙古族2型糖尿病"高危险"基因型。GMDR结果显示,一阶交互最优模型为rs3790433与超重/肥胖的交互作用模型(P<0.05)。结论LEPR、ADIPOR基因位点多态性与蒙古族2型糖尿病易感性相关,LEPR和ADIPOR2基因与环境的交互作用可能增加蒙古族2型糖尿病的发病风险。Objective To explore the interaction between genetic susceptibility of T2DM and LEPR gene rs3790433 and rs12037879,ADIPOR1 gene rs10920533,ADIPOR2 gene rs11061971 and environmental factors in Mongolian type 2 diabetes population.Methods A case-control study was carried out.The case group consisted of 238 Mongolians with type 2 diabetes from Hohhot,Xilinhot,and Tongliao.238 healthy Mongolians made comprised the control group.Multiple high temperature ligase detection reaction(iMLDR)was used to detect gene single nucleotide polymorphism(SNP).Generalized multi-factor dimensionality reduction(GMDR)was used to analyze the interaction between the gene and environmental factors.Results The genotype CC+CT of rs3790433 and the genotype AA+AT of rs 1106197 were“high risk”genotypes of T2DM in the Mongolian population(P>0.05).GMDR results show that the first-order interaction optimal model rs3790433,overweight/obesity has interaction(P<0.05).Conclusion The SNPs in the LEPR,ADIPOR1,and ADIPOR2 genes have been linked to T2DM susceptibility in the Mongolian population.The interaction of the LEPR and ADIPOR2 genes with environmental factors may increase the risk of T2DM in Mongolians.

关 键 词：蒙古族 2型糖尿病 单核苷酸多态性 环境因素 交互作用 

分 类 号：R587.1[医药卫生—内分泌]