PNEC-ILC2神经免疫通路在支气管哮喘中的研究进展  

Research progress of PNEC-ILC2 neuro-immune pathway in bronchial asthma

作　　者：黄帅阳 崔红生 候丹 吕明圣 黄贵锐 HUANG Shuaiyang;CUI Hongsheng;HOU Dan;LV Mingsheng;HUANG Guirui(The Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029,China;Beijing University of Chinese Medicine,Beijing 100029,China;不详)

机构地区：[1]北京中医药大学第三附属医院,北京100029 [2]北京中医药大学,北京100029

出　　处：《实用医学杂志》2022年第1期120-124,共5页The Journal of Practical Medicine

基　　金：国家自然基金面上资助项目(编号:82074390)。

摘　　要：本文通过认识肺神经内分泌细胞(pulmonary neuroendocrine cells,PNECs)和2型固有淋巴细胞(type 2 innate lymphoid cells,ILC2s)的结构和功能特点,归纳总结PNEC和ILC2在支气管哮喘中的作用。PNECs是由神经支配的一种特异性分化的气道上皮细胞,近年来很多的实验证据表明PNEC受感觉神经纤支配,表面可携带对缺氧和尼古丁等多种刺激敏感的膜受体,当受到外界环境环境变化或者过敏原的刺激后,可合成、储存和释放多种肽类激素。这些生物活性物质可直接或间接地影响肺组织的生理功能,并激活下游的ILC2s,加重哮喘中肺部T辅助2型细胞(Th2)免疫炎症,明确了PNEC-ILC2神经免疫通路在哮喘中可能的调控作用,从而进一步揭示哮喘复杂的作用机制。中医药在治疗哮喘方面疗效显著,且中医药多从多成分、多靶点进行,中医药是否在调控PNEC-ILC2神经免疫通路起作用尚无定论,本文试从PNEC-ILC2与哮喘、中医药的关系,拟为临床治疗哮喘,尤其是心理应激哮喘提供新的思路。In this article,we summarize the roles of pulmonary neuroendocrine cells(PNECs)and type 2 innate lymphoid cells(ILC2s)in bronchial asthma,by understanding the structural and functional characteristics of PNEC and ILC2.PNECs are specifically differentiated airway epithelial cells innervated by nerves.In recent years,increasing experimental evidence has shown that PNEC is in contact with sensory nerve fibers,and carries membrane receptors sensitive to various stimuli such as hypoxia and nicotine.PNECs can synthesize,storage and release of a variety of peptide hormones and other bioactive substances.These bioactive substances can directly or indirectly affect the physiological function of lung tissue and activate the downstream ILC2s,which further magnates the lung Th2 immune inflammation in asthma.In this paper,we clarified the possible regulatory role of PNEC-ILC2 neuroimmune pathway in asthma.Traditional Chinese medicine(TCM)is effective in the treatment of asthma,and TCM is mostly carried out from multiple components and multiple targets.Whether TCM plays a role in regulating the PNECILC2 neuroimmune module pathway is still unclear.This article attempts to provide new ideas for clinical treatment of asthma,especially psychological stress asthma,based on the relationship between PNEC-ILC2 and asthma and TCM.

关 键 词：肺神经内分泌细胞 2型固有淋巴细胞 神经免疫通路 哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]