姜黄素与胡椒碱在剂型与临床上联合应用的研究进展  

Research Progress on the Dosage Form and Clinical Combined Application of Curcumin and Piperine

作　　者：任金妹 马梦超 韩新宇 田思宇 谢宁 REN Jin-mei;MA Meng-chao;HAN Xin-yu;TIAN Si-yu;XIE Ning(Department of Pharmacy,Qingpu Branch of Zhongshan Hospital,Fudan University,Shanghai 201700,China;College of Pharmacy,Harbin Medical University,Harbin 150081,China)

机构地区：[1]复旦大学附属中山医院青浦分院药剂科,上海201700 [2]哈尔滨医科大学药学院,黑龙江哈尔滨150081

出　　处：《现代中药研究与实践》2021年第6期98-102,共5页Research and Practice on Chinese Medicines

基　　金：上海市临床药学重点专科建设项目(沪卫计药政〔2018〕9号);上海市青浦区医苑新星项目(WY2019-17);上海市青浦区科技发展基金项目(QKY2019-18);复旦大学附属中山医院青浦分院院级课题(QYP2020-03)。

摘　　要：姜黄素是从姜黄根茎中提取的多酚化合物,在很多疾病的预防和治疗中起到关键作用,然而,稳定性差、体内易代谢及生物利用度低限制了其临床应用。除了研发新剂型,与生物利用度增强剂胡椒碱的联用不仅能够改善姜黄素生物利用度,还具有药理作用上的协同效果。通过对姜黄素和胡椒碱在药物代谢动力学、药理作用和剂型研究三个方面进行综述,为新药研发提供思路。Curcumin is a polyphenol compound extracted from turmeric rhizomes and plays a key role in the prevention and treatment of many diseases.However,poor stability,metabolism easily in the body and low bioavailability limit its clinical application.In addition to the development of new dosage forms,the combination with piperine which is a bioavailability enhancer became a research direction.Combined application of curcumin and piperine can not only improve the bioavailability of curcumin,but also have synergistic effects on pharmacological effects.The aim of this study is to summarize the curcumin and piperine in three aspects,such as pharmacokinetics,pharmacological effects and dosage form studies,so as to provide ideas for the development of new drugs about curcumin and piperine.

关 键 词：姜黄素 胡椒碱 生物利用度 临床应用 新剂型 

分 类 号：R285.6[医药卫生—中药学]