甲基苯丙胺和海洛因标准物质研究进展  

Progress on Developing Reference Materials of Methamphetamine and Heroin

作　　者：杨虹贤[1] 闻武 郑珲[1] YANG Hongxian;WEN Wu;ZHENG Hui(Institute of Forensic Sciences,Ministry of Public Security,Beijing 100038,China)

机构地区：[1]公安部物证鉴定中心,北京100038

出　　处：《刑事技术》2022年第1期83-87,共5页Forensic Science and Technology

基　　金：中央级公益性科研院所基本科研业务费专项资金项目(2017JB010,2019JB020)。

摘　　要：甲基苯丙胺和海洛因是禁毒斗争的重要打击目标。毒品检测实验室在对甲基苯丙胺、海洛因相关检材进行定性定量分析时,必须依靠相应的高纯度标准物质作为分析参照,才能得出正确的检测结果。目前,尚未出现针对甲基苯丙胺和海洛因标准物质相关研究进展的报道。国内外现有生物基质甲基苯丙胺标准物质以及甲基苯丙胺纯度标准物质,可应用于体内外甲基苯丙胺的检测鉴定工作。其中,生物基质包括冻干尿液、毛发以及冷冻人体血清。海洛因除纯度标准物质外,已制备出了^(13)C标记的海洛因标准物质,^(13)C标记后的标准物质较氘代衍生物具有更高的分析精度。制备后的标准物质需经气相色谱-质谱法、液相色谱-质谱法、核磁共振波谱法、傅里叶变换红外光谱法等进行结构确认,同时通过气相色谱、液相色谱等不同定量分析方法进行量值。本文对上述国内外甲基苯丙胺和海洛因标准物质的研究情况进行概述,并展望了未来的研究方向。Methamphetamine and heroin are important targeting substances among the drugs that are fought against abuse and addiction.Routinely,drug testing laboratories must rely on the corresponding high-purity reference materials for the tested methamphetamine and heroin to get correct qualitative and quantitative analysis.At present,there are rare reports about the progress on developing reference materials of methamphetamine and heroin.Methamphetamine reference materials are currently available with their biological matrix-based ones and those certified versions home and abroad,having been applied into detection and identification of methamphetamine.The biological matrix-based reference materials include the products from frozen-dried urine,hair and frozen human serum.With addition of the certified ones,heroin reference materials have their^(13)C labeled preparations that excel in analytic precision to the deuterated derivative counterparts.The reference material should be confirmed of its structure with such approaches as gas chromatography-mass spectrometry,liquid chromatography-mass spectrometry,NMR and FTIR,together with its quantitative value being determined via different quantitative analysis choices,e.g.,gas chromatography and liquid chromatography.Through the summarization made here about the related researches and publications,a fuller understanding would be thus achieved on developing reference materials of methamphetamine and heroin.Finally,prospects were also proposed for their future researches and developments.

关 键 词：甲基苯丙胺 海洛因 标准物质 

分 类 号：D918.9[政治法律—法学]