MDMA前体PMK methyl glycidate的定性检验  

Qualitative Identification of PMK Methyl Glycidate,MDMA’s Precursor

作　　者：赵阳[1] 胡羽鹏 常颖[1] 高利生[1] ZHAO Yang;HU Yupeng;CHANG Ying;GAO Lisheng(Institute of Forensic Science,Ministry of Public Security,Beijing 100038,China;Huizhou Public Security Bureau,Huizhou 516001,Guangdong,China)

机构地区：[1]公安部物证鉴定中心,北京100038 [2]惠州市公安局,广东惠州516001

出　　处：《刑事技术》2022年第1期96-99,共4页Forensic Science and Technology

基　　金：公安部技术研究计划(2018JSYJC09);中央级公益性科研院所基本科研业务费专项资金项目(2019JB019)。

摘　　要：目的利用PMK methyl glycidate来合成胡椒基甲基酮(piperonyl methyl ketone,PMK),可进一步合成3,4-亚甲二氧基甲基苯丙胺(MDMA)。本文首次报道了中国大陆出现的PMK methyl glycidate,并应用气相色谱-质谱联用(GC-MS)和核磁共振(NMR)技术对化合物结构进行了分析与确证。方法样品分别用甲醇和DMSO-d_(6)提取后,使用GC-MS和NMR进行检测。结果通过GC-MS分析测得化合物的质谱特征碎片和保留时间信息,并对氢谱碳谱的信号峰进行归属,确定了化合物结构。结论该方法简便可靠,能用于PMK methyl glycidate的检验。Objective To report the first-time emergence of PMK(piperonyl methyl ketone)methyl glycidate(a precursor substance of MDMA)in Chinese mainland through completion of establishing its gas chromatography-mass spectrometry(GC-MS)analytical method and confirming its structure with nuclear magnetic resonance(NMR)which to deliver the compound’s hydrogen and carbon spectrums.PMK methyl glycidate is able to synthesize MDMA(3,4–methylenedioxymethamphetamine,a controlled drug capable of seducing the eater into addiction)through transition of PMK.Methods The sample was extracted with methanol and DMSO-d6,successively subjected to detection of GC-MS and NMR.Results GC-MS rendered the characteristic mass-spectral fragments and retention time of the extracted compound with which NMR assigned the signal peaks of both hydrogen and carbon spectrums,having therewith determined the structure of the chemical substance.Conclusions At present,GC-MS technology,combined with mass spectrometric information database retrieval,is one of the most commonly used choices for analyzing drugs and their precursors in forensic laboratories.However,due to the difficulty in obtaining available reference substances against the combination of some drugs and their precursors,the absolute accuracy of retrieval results cannot be guaranteed.NMR approach is independently eligible to confirm the structures of compounds of the reference substances so as to ensure the accuracy of the identification results.In this study,PMK methyl glycidate was identified with GC-MS and NMR,having its ^(1)H-NMR and ^(13)C-NMR spectra analyzed,thus providing a reference for identification of other similar compounds.The method is simple,reliable,and suitable for qualitative analysis of PMK methyl glycidate.

关 键 词：法医毒物学 甲基苯丙胺 胡椒基甲基酮 前体 气相色谱-质谱 核磁共振 

分 类 号：D919.1[医药卫生—法医学]