雌激素受体α基因rs2234693多态性与绝经后妇女骨质疏松症的meta分析  

Association between Estrogen Receptor a rs2234693 Polymorphisms and osteoporosis Risk in postmenopausal women:Evidence from a Meta-Analysis

作　　者：金佳佳 李姿萱 李永超 宋渐石 王冰霜 辛鸣 徐梦圆 王文娟[5] 刘冉[5] 王雪[5] 聂亚雄 张晓琳[5] Jin Jiajia;Li Zixuan;Li Yongchao;Song Jianshi;Wang Bingshuang;Xin Ming;Xu Mengyuan;Wang Wenjuan;Liu Ran;Wang Xue;Nie Yaxiong;Zhang Xiaolin(Department of basic medicine,Hebei Medical University,Shijiazhuang 050017,China;The second hospital of Hehei Medical University,Shijiazhuang 050017,China;Graduate school,Hebei Medical University,Shijiazhuang 050017,China;Department of basic medicine,North China University of Science and Technology,Tangshan 063210,China;Hebei Province Key Laboratoiy of Environment and Human Health,Department of Epidemiology'and Statistics,School of Public Health,Hebei Medical University,Shijiazhuang 050017,China)

机构地区：[1]河北医科大学基础医学院,石家庄050017 [2]河北医科大学第一附属医院,石家庄050017 [3]河北医科大学研究生学院,石家庄050017 [4]华北理工大学基础医学院,唐山063210 [5]河北省环境与人群健康重点实验室,河北医科大学流行病与卫生统计学教研室,石家庄050017

出　　处：《中华老年骨科与康复电子杂志》2021年第6期372-378,共7页Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition)

基　　金：河北医科大学大学生创新性实验计划项目(USIP2020222)。

摘　　要：目的本研究采用meta分析的方法,探讨了雌激素受体α(ERα)基因rs2234693位点多态性与绝经后妇女骨质疏松症的关系。方法检索CNKI、万方数据库、维普数据库、PubMed数据库,Google Scholar、Web of Science数据库,检索时限均从建库至2020年10月,收集国内外关于雌激素受体α基因rs2234639多态性与绝经后妇女骨质疏松症相关性的病例对照研究。采用NOS文献质量评价标准对符合纳入排除标准的文献进行质量评估,采用OR值及其95%可信区间(95%CI)评估关联强度。根据是否存在异质性,使用固定或随机效应模型计算合并效应量,绘制森林图和漏斗图进行meta分析。结果本研究最终共纳入符合标准的文献10篇,包括1364例病例和1482例对照。总样本2846例。亚洲人群等位基因模型中合并OR值为0.605,95%CI为(0.326,1.123),未发现rs2234639多态性与绝经后妇女骨质疏松症有关联,显性模型、隐性模型和共显性模型结果与之相同。高加索人群等位基因模型和共显性模型(PP:pp)显示二者存在关联,但显性模型、隐性模型和共显性模型(Pp:pp)未表现存在关联。在本研究中未发现发表偏倚(所有P>0.05)。结论在亚洲人群中,ERα基因的rs2234639位点多态性与绝经后妇女骨质疏松症之间无显著关联。但在高加索人群中P等位基因可降低绝经后妇女患骨质疏松症的风险。Objective To investigate the relationship between the estrogen receptor alpha(ERα) rs2234639 polymorphism and osteoporosis in postmenopausal women. Methods CNKI, Wanfang, China WeiPu Library, PubMed, Google Scholar and EMBASE were searched, the search time limit is from the establishment of the database to October 2020, randomized controlled studies were collected on the association between polymorphism of estrogen receptor gene rs2234639 and osteoporosis in postmenopausal women.The NOS literature quality evaluation standard was used to evaluate the quality of the literature meeting the inclusion and exclusion criteria, and the OR value and its 95% confidence interval(95% CI) were used to evaluate the strength of the association. According to the heterogeneity, the fixed or random effect models were used to calculate the combined effects, and forest diagrams and funnel diagrams were drawn for metaanalysis. Results The study finally included 10 articles that met the standards, including 1, 364 cases and1, 482 controls, with a total sample of 2, 846 cases. The pooled OR was 0.605 and 95% CI was(0.326, 1.123)in the allele model of Asian population. No association between rs2234639 polymorphism and postmenopausal osteoporosis was found. The results of dominant model, recessive model and co dominant model were the same. The allele model and co dominant model(PP: pp) of Caucasian population showed that they were associated, but the dominant model, recessive model and co dominant model(Pp:pp) did not. No publication bias was found in this study(all P>0.05). Conclusion There is no significant association between the rs2234639 polymorphism of ERα gene and osteoporosis in postmenopausal women in Asian population. But the P allele is associated with a reduced risk of osteoporosis in postmenopausal women in the Caucasian population.

关 键 词：基因多态性 骨质疏松症 雌激素受体 META分析 

分 类 号：R580[医药卫生—内分泌]