持续性胸段硬脊膜外麻醉在治疗颅脑外伤性应激性溃疡中的效果  

Effect of continuous thoracic epidural anesthesia in the treatment of stress ulcer caused by craniocerebral trauma

作　　者：王子轩 孙琳 张晓勇 韩景田 WANG Zi-xuan;SUN Lin;ZHANG Xiao-yong(Liaoning Health Industry Group Fukuang General Hospital,Fushun 113002,China)

机构地区：[1]辽宁省健康产业集团抚矿总医院,113002

出　　处：《中国现代药物应用》2022年第1期33-35,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析持续性胸段硬脊膜外麻醉在颅脑外伤性应激性溃疡中的治疗效果。方法 60例颅脑外伤性应激性溃疡患者,随机分为对照组和实验组,各30例。对照组实施常规治疗,实验组实施常规治疗+持续性胸段硬脊膜外麻醉治疗。比较两组临床指标及临床疗效。结果治疗后,实验组心率(74.26±12.37)次/min、呼吸频率(22.31±4.27)次/min、热休克蛋白70(HSP70)(1.61±0.37)ng/ml、热休克蛋白90(HSP90)(112.31±12.29)ng/ml低于对照组的(84.36±14.27)次/min、(27.26±6.31)次/min、(2.74±0.26)ng/ml、(127.34±14.25)ng/ml,中心静脉压(6.27±2.37)cm H_(2)O(1 cm H_(2)O=0.098 kPa)、血氧饱和度(97.25±7.16)%、胃部pH值(6.09±0.26)高于对照组的(4.93±2.17)cm H_(2)O、(91.27±7.29)%、(4.05±0.16),溃疡愈合时间(7.23±2.19)d短于对照组的(12.37±1.74)d,差异有统计学意义(P<0.05)。实验组治疗总有效率为96.67%,高于对照组的73.33%,差异有统计学意义(P<0.05)。结论将持续性胸段硬脊膜外麻醉治疗方法应用于颅脑外伤性应激性溃疡治疗过程中,能迅速控制病情,值得推广。Objective To analyze the effect of continuous thoracic epidural anesthesia in the treatment of stress ulcer caused by craniocerebral trauma. Methods A total of 60 cases of stress ulcer caused by craniocerebral trauma were randomly divided into control group and experimental group, with 30 cases in each group. The control group received conventional treatment, and the experimental group received conventional treatment and continuous thoracic epidural anesthesia. The clinical indicators and clinical efficacy of the two groups were compared. Results After treatment, the heart rate(74.26±12.37) beats/min, respiratory rate(22.31±4.27) breaths/min, heat shock protein 70(HSP70)(1.61±0.37) ng/ml, heat shock protein 90(HSP90)(112.31±12.29) ng/ml of the experimental group were lower than(84.36±14.27) times/min,(27.26±6.31) breaths/min,(2.74±0.26) ng/ml,(127.34±14.25) ng/ml of the control group;the central venous pressure(6.27±2.37) cm H_(2)O(1 cm H_(2)O=0.098 kPa), blood oxygen saturation(97.25±7.16)%, stomach pH(6.09±0.26)of the experimental group were higher than(4.93±2.17) cm H_(2)O,(91.27±7.29)%,(4.05±0.16) of the control group;the ulcer healing time(7.23±2.19) d of the experimental group were shorter than(12.37±1.74) d of the control group;all the differences were statistically significant(P<0.05). The total effective rate of treatment in the experimental group was 96.67%, which was higher than 73.33% in the control group, and the difference was statistically significant(P<0.05). Conclusion The application of continuous thoracic epidural anesthesia in the treatment of stress ulcer caused by craniocerebral trauma can quickly control the disease, and is worthy of promotion.

关 键 词：颅脑外伤 持续性胸段硬脊膜外麻醉 应激性溃疡 效果 

分 类 号：R614[医药卫生—麻醉学]