观察硝苯地平联合卡托普利治疗尿毒症合并难治性高血压病的临床疗效  

Clinical efficacy of nifedipine combined with captopril in the treatment of uremia complicated with refractory hypertension

作　　者：宋先梅 SONG Xian-mei(Dadong District People’s Hospital,Shenyang 110041,China)

机构地区：[1]沈阳市大东区人民医院,110041

出　　处：《中国现代药物应用》2022年第1期123-126,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究硝苯地平联合卡托普利治疗尿毒症合并难治性高血压病的临床疗效。方法 64例尿毒症合并难治性高血压病患者,依据治疗方案不同分为对照组与观察组,各32例。对照组给予硝苯地平治疗,观察组给予硝苯地平联合卡托普利治疗。对比两组治疗效果、治疗前后血压指标变化情况、肾功能指标、治疗期间不良反应发生情况。结果观察组治疗总有效率93.75%明显高于对照组的65.63%,差异有统计学意义(P<0.05)。治疗后,观察组舒张压(DBP)、收缩压(SBP)分别为(89.21±5.46)、(113.57±7.62)mm Hg(1 mm Hg=0.133 kPa),均低于对照组的(110.46±8.73)、(141.45±8.57)mm Hg,差异均有统计学意义(P<0.05)。观察组尿素氮(BUN)、血肌酐(Scr)、24 h尿蛋白定量、24 h排尿量均明显低于对照组,差异均有统计学意义(P<0.05)。两组治疗期间均未出现由药物引起的皮疹、腹泻、恶心呕吐、头痛头晕等不良反应。结论卡托普利联合硝苯地平治疗尿毒症合并难治性高血压疗效确切,具有较高临床安全性,可有效降低血压水平,对尿毒症治疗、改善肾功能有积极影响,可推广应用。Objective To investigate the clinical efficacy of nifedipine combined with captopril in the treatment of uremia complicated with refractory hypertension. Methods A total of 64 patients with uremia and refractory hypertension were divided into control group and observation group according to different treatment plans, with 32 cases in each group. The control group was treated with nifedipine, and the observation group was treated with nifedipine and captopril. The therapeutic effects, changes in blood pressure indicators and renal function indicators before and after treatment, and occurrence of adverse reactions during treatment were compared between the two groups. Results The total effective rate of treatment in the observation group was 93.75%, which was significantly higher than 65.63% in the control group, and the difference was statistically significant(P<0.05).After treatment, the diastolic blood pressure(DBP) and systolic blood pressure(SBP) of the observation group were(89.21±5.46) and(113.57±7.62) mm Hg(1 mm Hg=0.133 kPa), which were lower than(110.46±8.73),and(141.45±8.57) mm Hg of the control group, and the difference was statistically significant(P<0.05). The blood urea nitrogen(BUN), blood creatinine(Scr), 24-h urine protein quantification, and 24-h urine output of the observation group were significantly lower than those of the control group, and the differences were statistically significant(P<0.05). No adverse reactions caused by drugs such as rash, diarrhea, nausea and vomiting, headache and dizziness occurred during treatment in both groups. Conclusion The combined treatment of captopril and nifedipine has definite efficacy on uremic patients with refractory hypertension, and can effectively reduce blood pressure, which is useful for the treatment of uremia and improvement of renal function. It can be promoted and applied.

关 键 词：尿毒症 难治性高血压 硝苯地平 卡托普利 

分 类 号：R544.1[医药卫生—心血管疾病] R692.5[医药卫生—内科学]