阿奇霉素联合头孢哌酮钠舒巴坦钠治疗老年肺炎的效果分析  

Effect analysis of azithromycin combined with cefoperazone sodium and sulbactam sodium in the treatment of senile pneumonia

作　　者：木安红 MU An-hong(Chaoyang Fourth Hospital,Chaoyang 122000,China)

机构地区：[1]朝阳市第四医院,122000

出　　处：《中国现代药物应用》2022年第1期126-128,共3页Chinese Journal of Modern Drug Application

摘　　要：目的研究阿奇霉素联合头孢哌酮钠舒巴坦钠治疗老年肺炎的临床效果。方法 94例老年肺炎患者,根据治疗方式不同将其分为研究组与对照组,每组47例。对照组采用阿奇霉素进行治疗,研究组采用阿奇霉素联合头孢哌酮钠舒巴坦钠治疗。对比两组临床疗效、治疗期间不良反应发生情况、临床症状改善时间、治疗前后炎性因子指标。结果研究组治疗总有效率97.87%高于对照组的80.85%,差异有统计学意义(P<0.05)。研究组治疗期间不良反应发生率4.26%低于对照组的21.28%,差异有统计学意义(P<0.05)。研究组体温、痰液颜色、白细胞计数、湿啰音改善时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,研究组C反应蛋白(2.13±0.05)mg/L、白细胞水平(3.52±1.34)×10^(9)/L,均低于对照组的(5.56±0.25)mg/L、(6.25±2.52)×10^(9)/L,差异均有统计学意义(P<0.05)。结论老年肺炎患者应用阿奇霉素联合头孢哌酮钠舒巴坦钠治疗效果显著,可明显提高临床疗效,改善炎性反应,缩短疾病的恢复时间,降低不良反应发生率,具有较高的安全性。Objective To study the clinical effect of azithromycin combined with cefoperazone sodium and sulbactam sodium in the treatment of senile pneumonia. Methods A total of 94 elderly patients with pneumonia were divided into research group and control group according to different treatment methods, with 47 cases in each group. The control group was treated with azithromycin, and the research group was treated with azithromycin and cefoperazone sodium and sulbactam sodium. Both groups were compared in terms of clinical efficacy, occurrence of adverse reactions during treatment, improvement time of clinical symptoms, and inflammatory factors before and after treatment. Results The total effective rate of treatment 97.87% in the research group was higher than 80.85% in the control group, and the difference was statistically significant(P<0.05).The incidence of adverse reactions during treatment 4.26% in the research group was lower than 21.28% in the control group, and the difference was statistically significant(P<0.05). The improvement time of body temperature,sputum color, white blood cell count, and wet rales in the research group was shorter than those in the control group, and the difference was statistically significant(P<0.05). After treatment, the C-reactive protein(2.13±0.05) mg/L and white blood cell(3.52±1.34)×10^(9)/L in the research group were lower than(5.56±0.25) mg/L and(6.25±2.52)×10^(9)/L in the control group, and the difference was statistically significant(P<0.05). Conclusion The use of azithromycin combined with cefoperazone sodium and sulbactam sodium has significant effect on elderly patients with pneumonia, and it can significantly improve the clinical efficacy and inflammatory response,shorten the recovery time of the disease, reduce the incidence of adverse reactions, has the high security.

关 键 词：头孢哌酮钠舒巴坦钠 阿奇霉素 老年肺炎 临床疗效 炎性指标 

分 类 号：R563.1[医药卫生—呼吸系统]