对急诊哮喘患儿实施万托林联合普米克令舒雾化吸入治疗的临床效果  

Clinical effect of Ventolin combined with Pulmicort Respules aerosol inhalation therapy for children with acute asthma

作　　者：教野 JIAO Ye(Department of Pediatrics,People’s Hospital of Shenyang Economic and Technological Development Zone,Shenyang 110000,China)

机构地区：[1]沈阳经济技术开发区人民医院儿科,110000

出　　处：《中国现代药物应用》2022年第1期144-147,共4页Chinese Journal of Modern Drug Application

摘　　要：目的对哮喘患儿治疗情况进行探究,以期证实硫酸沙丁胺醇吸入气雾剂(商品名:万托林)、吸入用布地奈德混悬液(商品名:普米克令舒)雾化吸入结合方案的有效性、可行性。方法 82例哮喘患儿,按照随机数字表法分为对照组及研究组,每组41例。对照组单独采用万托林氧气驱动雾化吸入治疗,研究组采用万托林+普米克令舒氧气驱动雾化吸入治疗。比较两组临床疗效、肺功能指标(第1秒用力呼气容积、用力肺活量、呼气流量峰值)及不良反应发生情况。结果研究组总有效率95.12%高于对照组的78.05%,差异有统计学意义(P<0.05)。用药1周后,两组第1秒用力呼气容积、用力肺活量、呼气流量峰值均较用药前升高,且研究组第1秒用力呼气容积(1.89±0.41)L、用力肺活量(2.81±0.61)L、呼气流量峰值(198.61±28.33)L/min高于对照组的(1.41±0.29)L、(2.23±0.45)L、(174.61±26.29)L/min,差异具有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论万托林、普米克令舒雾化吸入结合方案可取得满意效果,优化急诊哮喘患儿临床疗效,改善肺功能,减轻症状,以及保障患儿用药安全。Objective To discuss the effectiveness and feasibility of salbutamol sulphate aerosol(trade name: Ventolin) combined with budesonide suspension for inhalation(trade name: Pulmicort Respules) aerosol inhalation therapy for children with acute asthma. Methods A total of 82 children with asthma were divided into control group and research group according to the random numerical table, with 41 cases in each group. The control group was treated with Vantoline oxygen-driven aerosol inhalation, and the research group was treated with Vantuolin and Pulmicort Respules oxygen-driven aerosol inhalation. The clinical efficacy, pulmonary function indexes(forced expiratory volume in the 1 st second, forced vital capacity, peak expiratory flow) and the occurrence of adverse reactions were compared between the two groups. Results The total effective rate 95.12%of the research group was higher than 78.05% of the control group, and the difference was statistically significant(P<0.05). After 1 week of medication, the forced expiratory volume in the 1 st second, forced vital capacity, and peak expiratory flow of the two groups were higher than those of this group before medication;the forced expiratory volume in the 1 st second(1.89±0.41) L, and the forced vital capacity(2.81±0.61) L and peak expiratory flow(198.61±28.33) L/min of the research group were higher than(1.41±0.29) L,(2.23±0.45) L, and(174.61±26.29) L/min of the control group. All the differences were statistically significant(P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Vantolin and Pulmicort Respules aerosol inhalation can achieve satisfactory results, optimize the clinical efficacy of children with emergency asthma, improve lung function, reduce symptoms,and ensure the safety of medication in children.

关 键 词：哮喘 硫酸沙丁胺醇吸入气雾剂 吸入用布地奈德混悬液 雾化吸入 临床疗效 肺功能 不良反应 

分 类 号：R725.6[医药卫生—儿科]