丙戊酸致肝毒性影响因素及早期预警标志物研究进展  

A Systematic Review on Risk Factors and Biomarkers of Valproic Acid for Early Warning of Hepatotoxicity

作　　者：章静欣 赵明明[1] 郭帅帅 肇丽梅[1] ZHANG Jing-xin;ZHAO Ming-ming;GUO Shuai-shuai;ZHAO Li-mei(Department of Pharmacy,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院药学部,沈阳110004

出　　处：《中国药学杂志》2021年第24期1957-1961,共5页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(81703628)。

摘　　要：丙戊酸为一线广谱抗癫痫药物,临床应用广泛,丙戊酸致肝毒性是其严重不良反应之一,且受患者年龄、联合用药及基因多态性等因素影响,如何早期预警丙戊酸致肝毒性已成为临床治疗中亟待解决的问题。笔者主要综述了影响丙戊酸致肝毒性的危险因素、丙戊酸致肝毒性生物标志物研究进展,为丙戊酸的临床应用及相关研究提供参考。Valproic acid is a first-line broad-spectrum antiepileptic drug,which is widely used in clinic.Hepatotoxicity caused by valproic acid is one of its serious adverse reactions,and affected by patient age,combined medication and gene polymorphism.During valproic acid treatment,how to prevent the occurrence of liver toxicity in the early stage has become the focus of research.This paper reviews the risk factors of valproic acid induced hepatotoxicity and the research progress of biomarkers of valproic acid induced hepatotoxicity,so as to provide reference for the clinical application and related research of valproic acid.

关 键 词：丙戊酸 肝毒性 风险因素 生物标志物 

分 类 号：R969.3[医药卫生—药理学]