骨质疏松性胸腰椎压缩骨折经皮椎体强化治疗后残余痛的危险因素  

Risk factors of residual pain after percutaneous vertebral augmentation for osteoporotic thoracolumbar compression fractures

作　　者：刘晨 胡铖哲 尹逊 喻子恒 杨建东 Liu Chen;Hu Chengzhe;Yin Xun;Yu Ziheng;Yang Jiandong(Medical College of Yangzhou University,Yangzhou 225001,Jiangsu Province,China;Department of Spinal Surgery,Clinical Medical School of Yangzhou University/Northern Jiangsu People’s Hospital,Yangzhou 225001,Jiangsu Province,China;Dalian Medical University,Dalian 116000,Liaoning Province,China)

机构地区：[1]扬州大学医学院,江苏省扬州市225001 [2]扬州大学临床医学院/江苏省苏北人民医院脊柱外科,江苏省扬州市225001 [3]大连医科大学,辽宁省大连市116000

出　　处：《中国组织工程研究》2022年第18期2900-2905,共6页Chinese Journal of Tissue Engineering Research

基　　金：扬州市重点研发计划(社会发展)项目(YZ2020080),项目负责人:杨建东。

摘　　要：背景:经皮椎体强化治疗后残余痛是影响患者生活质量的严重并发症之一,也是困扰临床医生的难题。目前已有一些研究分析了椎体强化治疗后残余痛的危险因素,但不够全面且发生机制不甚清晰。目的:分析骨质疏松性胸腰椎压缩骨折椎体强化治疗后残余痛的危险因素,并探讨其发生机制。方法:选择2019年10月至2021年1月在江苏省苏北人民医院脊柱外科接受经皮椎体强化治疗的骨质疏松性椎体压缩骨折的患者共217例。术后1周及术后1,3,6个月内任意一次随访目测类比评分≥4分则认为有术后残余痛,依据有无残余痛的情况分为残余痛组(n=33)、无残余痛组(n=184)。调查两组患者性别、年龄、体质量指数、病程、慢性病史、外伤史、骨折椎体部位、腰背痛史、腰背筋膜损伤、骨密度、邻椎骨折、手术方式、骨水泥量、骨水泥渗漏情况、术前椎体高度压缩率、术后椎体高度恢复率、术后Cobb角改善率等资料,采用单因素及多因素Logistic回归分析探讨患者术后残余痛的危险因素。结果与结论:①两组患者的性别、年龄、病程、慢性病史、骨折椎体部位、手术方式、骨水泥量、骨水泥渗漏情况、术前椎体高度压缩率比较,差异均无显著性意义(P>0.05);②两组患者的体质量指数、外伤史、腰背筋膜损伤、腰背痛史、骨密度、邻椎骨折、术后椎体高度恢复率、术后Cobb角改善率比较,差异均有显著性意义(P<0.05);③对相关因素进行Logistic回归分析显示,体质量指数、腰背筋膜损伤、骨密度、邻椎骨折、术后椎体高度恢复率、术后Cobb角改善率是术后残余腰痛的危险因素(P<0.05);④结果表明体质量指数、腰背筋膜损伤、骨密度、邻椎骨折、术后椎体高度恢复率、术后Cobb角改善率是引起术后残余痛的危险因素,在临床工作中应采取相应预防性措施,从而减少术后残余痛发生。BACKGROUND:Residual pain after percutaneous vertebral augmentation is one of the serious complications affecting the quality of life of patients,and also a difficult problem for clinicians.At present,some studies have analyzed the risk factors of residual pain after vertebral body strengthening,but they are not comprehensive and the mechanism is not clear.OBJECTIVE:To analyze the risk factors of residual pain after vertebral body strengthening in osteoporotic thoracolumbar compression fractures,and to explore its mechanism.METHODS:A total of 217 patients with osteoporotic vertebral compression fractures who received percutaneous vertebral augmentation in the Department of Spinal Surgery,Northern Jiangsu People’s Hospital from October 2019 to January 2021 were selected.Postoperative residual pain was considered if the visual analogue scale score was≥4 at 1 week,1,3,and 6 months after surgery.According to whether there was residual pain,patients were divided into residual pain group(n=33)and no residual pain group(n=184).Gender,age,body mass index,the course of the disease,chronic medical history,history of trauma,vertebral fracture site,history of low back pain,lumbodorsal fascia injury,bone mineral density,adjacent vertebral fractures,surgical procedure,amount of bone cement,bone cement leakage,preoperative vertebral height compression rate,postoperative vertebral height recovery rate,and improvement rate of postoperative Cobb angle were surveyed between the two groups.Univariate and multivariate Logistic regression analyses were used to investigate the risk factors of postoperative residual pain.RESULTS AND CONCLUSION:(1)There was no significant difference in gender,age,course of disease,chronic history,vertebral fracture site,surgical method,amount of bone cement,bone cement leakage,and preoperative vertebral height compression rate between the two groups(P>0.05).(2)There were statistically significant differences in body mass index,trauma history,lumbodorsal fascia injury,history of low back pain,bone mine

关 键 词：骨质疏松 椎体骨折 椎体强化 骨水泥 残余痛 并发症 危险因素 组织工程 

分 类 号：R459.9[医药卫生—治疗学] R496[医药卫生—临床医学]