基于知识图谱的骨缺损治疗可视化分析  

Visualization analysis of bone defect treatment based on knowledge map

作　　者：董佳乐 魏远好 张洪武 Dong Jiale;Wei Yuanhao;Zhang Hongwu(The First School of Clinical Medicine,Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering,Southern Medical University,Guangzhou 510515,Guangdong Province,China;School of Basic Medical Sciences,Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering,Southern Medical University,Guangzhou 510515,Guangdong Province,China)

机构地区：[1]南方医科大学第一临床医学院,广东省广州市510515 [2]南方医科大学基础医学院广东省组织构建与检测重点实验室,广东省广州市510515

出　　处：《中国组织工程研究》2022年第18期2906-2913,共8页Chinese Journal of Tissue Engineering Research

基　　金：广东省省级科技计划项目(2020A0505100050),项目参与人:张洪武;广东省自然科学基金(2020A1515010102),项目负责人:张洪武。

摘　　要：背景:骨缺损作为运动系统的常见疾病,采用有效手段对其进行治疗具有十分重要的意义,但目前国内尚缺少使用文献计量学对骨缺损治疗进行研究的文献综述。目的:针对近10年来发表的骨缺损治疗文献进行文献计量学分析,探究该领域的研究现状、研究热点和研究趋势,并为其未来发展提供意见与建议。方法:以Web of Science Core Collection数据库为数据来源,分析2011-2020年间骨缺损治疗文献年发文量及基金资助情况,并使用CiteSpace V软件分析该领域有关研究的作者、国家、机构合作情况、期刊及文献共被引情况;此外还针对关键词进行聚类分析、突现分析及时区分析,绘制可视化知识图谱。结果与结论:共纳入1743篇有效文献。①2011-2020间整体发文量呈稳步上升趋势,科研基金方面以中国国家自然科学基金资助项目最多(23.81%)。②中国和上海交通大学分别为该领域发文量最多的国家与研究机构。美国及中国科学院中心性最强,分别起该领域学术枢纽作用。③共纳入作者476位,Lei Zhang、Changsheng Liu和Ana Claudia Muniz Renno为发文最多的研究人员,但核心作者间未形成紧密合作关系。④《Biomaterials》杂志是收录文章最多的期刊,在生物材料领域期刊中具有权威地位。⑤修复、再生、体外、支架、间充质干细胞分别为该领域的研究热点。⑥时区分析显示,前期的研究策略主要是骨缺损的诱导分化、促进再生;从2015年开始,纳米颗粒、水凝胶等材料借助3D打印技术逐渐广泛应用于骨缺损治疗中;近年来,研究者期望在信号通路水平探究骨缺损治疗机制,并期望使用新型复合材料支架联合药物/生长因子控释技术达到更好的治疗效果。⑦预测骨缺损治疗未来的发展方向为:使用3D打印等技术,继续制备具有良好机械性能的新型纳米复合材料支架;制备可双重/多重控释的药物和(或)生长�BACKGROUND:As a common disease of the motor system,bone defect is of great significance to be treated by effective means.However,there is still a lack of literature review on the treatment of bone defect by bibliometrics in China.OBJECTIVE:To analyze the literature on the treatment of bone defect published in recent 10 years and to explore the research status,hotspots,and trends in this field,and to provide opinions and suggestions for its future development.METHODS:Using Web of Science Core Collection database as the data source and the application of bibliometrics,CiteSpace V software was used to draw the knowledge map and conduct cluster analysis of the annual trends,the distribution of nations,the distribution of research institution,the distribution of authors and the key words in the field of bone defect treatment from 2011 to 2020.RESULTS AND CONCLUSION:A total of 1743 valid articles were selected.(1)The volume of publications shows a steady rise from 2011 to 2020 in general.In terms of scientific research funds,the National Natural Science Foundation of China funded the most projects(23.81%).(2)China and Shanghai Jiao Tong University are the country and research institution with the most publications in this field respectively.USA and Chinese Academy of Sciences play the role of academic hub with the strongest centrality.(3)A total of 476 authors were included.Lei Zhang,Changsheng Liu,and Ana Claudia Muniz Renno were the most prolific researchers,but the core authors did not form a close cooperative relationship.(4)Biomaterials is the journal with the largest number of articles,and has an authoritative position in the field of biological materials.(5)Repair,regeneration,in vitro,scaffold,and mesenchymal stem cell are the research hotspots in this field.(6)Time zone analysis showed that the previous research strategies were mainly for inducing differentiation and promoting regeneration of bone defects.Since 2015,nanoparticles,hydrogels and other materials are gradually widely used in the treatment of bone

关 键 词：骨缺损 CITESPACE 知识图谱 可视化分析 纳米复合材料 复合材料支架 3D打印技术 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]