磷酸肌酸与果糖二磷酸钠治疗小儿心肌炎的疗效比较  

Comparison of efficacy of creatine phosphate and fructose sodium diphosphate in the treatment of infantile myocarditis

作　　者：孙强 SUN Qiang(Department of Pediatrics,Maternal and Child Health Care and Family Planning Service Center of Xiuyan Manchu Autonomous County,Anshan 114300,China)

机构地区：[1]岫岩满族自治县妇幼保健计划生育服务中心儿科,114300

出　　处：《中国实用医药》2022年第1期117-120,共4页China Practical Medicine

摘　　要：目的探讨磷酸肌酸与果糖二磷酸钠治疗小儿心肌炎的疗效。方法100例小儿心肌炎患儿,采用随机数字表法分为试验组和参照组,每组50例。试验组患儿采用磷酸肌酸治疗,参照组患儿采取果糖二磷酸钠治疗。比较两组患儿治疗效果及治疗前后心肌肌钙蛋白I(cTnI)、收缩期最大血流速度和舒张期血流速度比值、心肌酶谱指标[肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)]。结果治疗后,试验组患儿心肌肌钙蛋白I水平(0.12±0.01)μg/L低于参照组的(0.71±0.13)μg/L,收缩期最大血流速度和舒张期血流速度比值(1.58±0.24)高于参照组的(1.24±0.19),差异均有统计学意义(P<0.05)。治疗后,试验组患儿肌酸激酶、乳酸脱氢酶及肌酸激酶同工酶水平显著低于参照组,差异有统计学意义(P<0.05)。试验组患儿治疗总有效率为96.00%,高于参照组的78.00%,差异有统计学意义(P<0.05)。结论磷酸肌酸能显著提高小儿心肌炎患儿的心肌功能,改善心肌血液循环,减少心肌损害,值得临床推广。Objective To discuss the efficacy of creatine phosphate and fructose sodium diphosphate in the treatment of infantile myocarditis.Methods A total of 100 children with infantile myocarditis were divided into experimental group and reference group by random numerical table,with 50 cases in each group.Children in the experimental group were treated with creatine phosphate,and children in the reference group were treated with fructose sodium diphosphate.Both groups were compared in terms of therapeutic effect,cardiac troponin I(cTnI),peak systolic velocity/end diastolic velocity,and cardiac enzyme profile indices[creatine kinase(CK),creatine kinase isoenzyme(CK-MB),and lactate dehydrogenase(LDH)]before and after treatment.Results After treatment,the cardiac troponin I(0.12±0.01)μg/L in the experimental group was lower than(0.71±0.13)μg/L in the reference group,and the peak systolic velocity/end diastolic velocity(1.58±0.24)was higher than(1.24±0.19)in the reference group.All the differences were statistically significant(P<0.05).After treatment,the levels of creatine kinase,lactate dehydrogenase and creatine kinase isoenzymes in the experimental group were significantly lower than those in the reference group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the experimental group was 96.00%,which was higher than 78.00%in the reference group,and the difference was statistically significant(P<0.05).Conclusion Creatine phosphate can significantly improve the myocardial function and myocardial blood circulation and reduce myocardial damage in children with myocarditis,which is worthy of clinical promotion.

关 键 词：磷酸肌酸 果糖二磷酸钠 小儿心肌炎 

分 类 号：R725.4[医药卫生—儿科]