阿替普酶溶栓引起严重不良反应1例及文献分析  

One Case of Severe Adverse Drug Reactions Induced by rt-PA and Literature Analysis

作　　者：付虹[1] 戎有和[2] FU Hong;RONG Youhe(Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing Jiangsu 210029,China;Nanjing University of Traditional Chinese Medicine,Nanjing Jiangsu 210029,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029 [2]南京中医药大学,江苏南京210029

出　　处：《中国药物警戒》2021年第12期1198-1200,共3页Chinese Journal of Pharmacovigilance

基　　金：江苏省药学会奥赛康医院药学基金(A201902);江苏省药学会天晴医院药学基金(Q2018011)。

摘　　要：目的探讨阿替普酶溶栓过程中引起严重过敏反应的机制和处理措施。方法通过介绍1例阿替普酶引起严重过敏反应的病例的诊疗经过,结合文献分析阐述阿替普酶引起过敏反应的可能机制和处理方法。结果经过积极对症处理,患者严重的过敏反应明显好转并趋于稳定。结论阿替普酶引起严重的过敏反应虽然罕见,但是会对患者造成生命的威胁,需要在以后的工作中重视此类不良反应,并积极进行对症处理。Objective To discuss the mechanism and treatment of severe adverse drug reactions caused by rtPA.Methods Based on the diagnosis and treatment of one case with severe allergic reactions caused by rtPA,the possible mechanism and treatments were described in combination with literature analysis.Results After effective treatment,the patient improved significantly and tended to be stable.Conclusion The severe anaphylaxis caused by rt-PA is rare but life-threatening,so we need to pay more attention to the adverse reactions in our future work and deal with them properly.

关 键 词：阿替普酶 过敏 溶栓 严重不良反应 

分 类 号：R994.11[医药卫生—毒理学]