IL-17、IL-10在类风湿性关节炎患者滑膜组织中的水平及意义  

The Levels and Significance of IL-17 and IL-10 in Synovium Tissue of Patients with Rheumatoid Arthritis

作　　者：赵震 胡惠军[1] 古彩红[1] ZHAO Zhen;HU Hui-jun;GU Cai-hong(Huizhou Third People's Hospital,Guangdong Huizhou 516000)

机构地区：[1]惠州市第三人民医院,广东惠州516000

出　　处：《深圳中西医结合杂志》2021年第21期81-83,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探究白细胞介素(IL)-17、IL-10在类风湿性关节炎(RA)患者滑膜组织中的水平及意义。方法:选取2016年3月至2019年4月于惠州市第三人民医院经病理诊断为RA的手术切除滑膜组织标本80例为RA组,另选取20例骨性关节炎(OA)标本作为对照组(OA组)。两组均行免疫组化EnVision法染色。比较两组患者IL-17、IL-10在滑膜组织中的水平差异,并分析IL-17与IL-10的相关性。结果:IL-17在RA组的阳性率高于(OA组),差异具有统计学意义(P<0.05);两组标本的IL-10阳性率比较,差异无统计学意义(P>0.05);IL-17、IL-10在滑膜被覆细胞的阳性率和滑膜下组织中的阳性率比较,差异均无统计学意义(P>0.05)。经Spearman相关性检验,RA组的IL-17与IL-10水平呈负相关(r=-0.623,P<0.05)。结论:IL-17在RA患者滑膜组织中的水平显著升高,IL-10则有一定的降低,且患者的IL-17与IL-10表达呈负相关,两者表达失衡在RA发病预测中具有一定价值。Objective To investigate the level and significance of interleukin(IL)-17 and IL-10 in Synovium tissue of patients with rheumatoid arthritis(RA).Methods From March 2016 to April 2019,80 cases of surgically resected Synovium tissue specimens diagnosed as RA in Huizhou Third People's Hospital were selected as the observation group,and 20 cases of osteoarthritis(OA)specimens were selected as the control group.Immunohistochemical envision staining was performed in both groups.The levels of IL-17 and IL-10 in synovial tissue were compared between the two groups,and the correlation between IL-17 and IL-10 was analyzed.Results The positive rate of IL-17 in RA group was higher than that in control group(P<0.05);There was no significant difference in the positive rate of IL-10 between the two groups(P>0.05);There was no significant difference in the positive rates of IL-17 and IL-10 in synovial coated cells and subsynovial tissues(P>0.05).Spearman rank correlation test showed that there was a negative correlation between IL-17 and IL-10 in RA group(r=-0.623,P<0.05).Conclusion The level of IL-17 in synovial tissue of RA patients increased significantly,while IL-10 decreased to a certain extent,and there is a negative correlation between the expression of IL-17 and IL-10.The imbalance of their expression has a certain value in the prediction of the pathogenesis of RA.

关 键 词：类风湿性关节炎 滑膜组织 白细胞介素-17 白细胞介素-10 

分 类 号：R684.3[医药卫生—骨科学]