黄体酮胶囊治疗闭经与无排卵型功能失调性子宫出血的效果观察  

Observation on the Efficacy of Progesterone Capsule in the Treatment of Amenorrhea and Ovulatory Dysfunctional Abnormal Uterine Bleeding

作　　者：周佩端 王芝 ZHOU Pei-duan;WANG Zhi(Puning People's Hospital,Guangdong Puning 515300)

机构地区：[1]普宁市人民医院,广东普宁515300

出　　处：《深圳中西医结合杂志》2021年第21期136-138,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨黄体酮胶囊治疗闭经与无排卵型功能失调性子宫出血(AUB-O)的临床效果。方法:选取普宁市人民医院在2019年6月至2020年5月期间诊治的84例闭经与AUB-O患者,采用随机数字表法分为两组,对照组和观察组各42例。两组均给予戊酸雌二醇治疗,同时对照组采用醋酸甲羟孕酮治疗,观察组采用黄体酮治疗。比较两组患者治疗的效果,治疗前后月经周期、经期和月经失血图评分法(PBAC)评分变化情况,以及不良反应发生情况。结果:观察组患者治疗总有效率明显高于对照组(95.24%vs 71.43%),差异具有统计学意义(P<0.05)。治疗前,两组闭经与AUB-O患者月经周期、经期和PBAC评分均无显著差异(P>0.05);治疗后,两组闭经患者月经周期、经期和PBAC评分均明显增加,AUB-O患者月经周期、经期和PBAC评分均明显减少,且观察组优于对照组,差异均具有统计学意义(P<0.05)。观察组患者不良反应发生率明显低于对照组(7.14%vs 23.81%),差异具有统计学意义(P<0.05)。结论:对闭经与AUB-O采用黄体酮胶囊治疗,可以改善月经状况,显著提升患者临床疗效,且安全性也较高。Objective To investigate the clinical effect of progesterone capsule in the treatment of amenorrhea and ovulatory dysfunctional abnormal uterine bleeding(AUB-O).Methods 84 patients with amenorrhea and AUB-O treated in Puning People's Hospital from June 2019 to may 2020 were selected.The patients were randomly divided into two groups using randomized digital table method,with 42 cases in the control group and 42 cases in the observation group.Both groups were treated with estradiol valerate,while the control group was treated with medroxyprogesterone acetate,and the observation group was treated with progesterone.The effects of treatment,the changes of menstrual cycle,menstrual period and the score of pictorial blood loss assessment chart(PBAC)before and after treatment,and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(95.24%vs 71.43%),(P<0.05).Before treatment,there was no significant difference in menstrual cycle,menstrual period and PBAC score between the two groups(P>0.05).After treatment,the menstrual cycle,menstrual period and PBAC scores of amenorrhea patients in the two groups increased significantly,and the menstrual cycle,menstrual period and PBAC scores of AUB-O patients in the two groups decreased significantly,and the indexes of the observation group were significantly better than those of the control group(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(7.14%vs 23.81%)(P<0.05).Conclusion Progesterone capsule for amenorrhea and AUB-O can improve menstrual status,significantly improve the clinical efficacy and safety.

关 键 词：无排卵型功能失调性子宫出血 闭经 黄体酮胶囊 醋酸甲羟孕酮 

分 类 号：R711.52[医药卫生—妇产科学]