微生态制剂对哮喘患儿疗效、心理问题及认知功能的干预效果  

Intervention effect of microbial ecological agent on efficacy,psychological problems and cognitive function in children with asthma

作　　者：沙曦雪 王苏弘[2] 杨彧[3] 顾燕明[1] 庞高峰[1] 宁晶晶[1] 胡文君[1] 李静波[1] 倪慧萍[1] SHA Xixue;WANG Suhong;YANG Yu;GU Yanming;PANG Gaofeng;NING Jingjing;HU Wenjun;LI Jingbo;NI Huiping(Department of Pediatrics,the First People's Hospital of Changzhou City in Jiangsu Province,Changzhou213003,China;Department of Clinical Psychology,the First People's Hospital of Changzhou City in Jiangsu Province,Changzhou213003,China;Department of Pharmacy,the First People's Hospital of Changzhou City in Jiangsu Province,Changzhou213003,China)

机构地区：[1]江苏省常州市第一人民医院儿科,江苏常州213003 [2]江苏省常州市第一人民医院临床心理科,江苏常州213003 [3]江苏省常州市第一人民医院药学部,江苏常州213003

出　　处：《中国现代医生》2022年第1期89-92,共4页China Modern Doctor

基　　金：妇幼保健协会科研课题(FYX202021)。

摘　　要：目的分析微生态制剂对哮喘患儿疗效、心理问题及认知功能的干预效果。方法选取2020年1月至2021年1月常州市第一人民医院收治的200例哮喘患儿,随机分为观察组和对照组,每组各100例,均给予支气管哮喘常规治疗,观察组加用微生态制剂,两组治疗均持续3个月。另选取同期年龄、性别匹配的健康体检儿童50名,将其纳入健康组。比较观察组和对照组患儿治疗前后疗效、心理问题及认知功能变化,分析微生态制剂的临床价值。结果观察组、对照组治疗前、治疗后CBCL、PSQ评分均高于健康组,其综合注意力商数低于健康组;两组治疗后CBCL、PSQ评分均较治疗前下降,综合注意力商数较治疗前升高,观察组治疗后CBCL、PSQ评分低于对照组,其综合注意力商数高于对照组,差异有统计学意义(P<0.001,P<0.05)。观察组、对照组治疗后CACT评分均较治疗前升高,观察组治疗后C-ACT评分高于对照组,差异有极其显著的统计学意义(P<0.001)。治疗后观察组总有效率为95.00%,高于对照组的76.00%,差异有极其显著的统计学意义(P<0.001)。观察组、对照组治疗期间均未见不良反应发生。结论哮喘患儿普遍存在心理问题及认知下降,在常规综合治疗的基础上加用微生态制剂干预,能够改善患儿心理问题、提高认知功能,对于哮喘症状的改善亦有着积极作用。Objective To analyze the intervention effect of microbial ecological agent on efficacy,psychological problems and cognitive function in children with asthma.Methods A total of 200 children with asthma admitted to the First People's Hospital of Changzhou from January 2020 to January 2021 were randomly divided into observation group(n=100)and control group(n=100).All patients were given routine treatment for bronchial asthma,and the observation group was treated with microbial ecological agent.The treatment in both groups lasted for three months.Fifty healthy children with age and sex matching were selected as the healthy group during the same period.The efficacy,psychological problems and cognitive function changes before and after treatment were compared between the observation group and the control group,and the clinical value of the microbial ecological agent was analyzed.Results The scores of CBCL and PSQ in the observation group and the control group before and after treatment were higher than those in the healthy group,and their comprehensive attention quotient was lower than that in the healthy group.The CBCL and PSQ in the two groups after treatment were lower than those before treatment,and their comprehensive attention quotient was higher than before treatment.The CBCL and PSQ in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P<0.001,P<0.05).The C-ACT score between the observation group and the control group after treatment was higher than that before treatment.The C-ACT score in the observation group after treatment was higher than that in the control group,and the difference had extremely statistical significance(P<0.001).After treatment,the effective rate in the observation group was 95.00%,which was higher than that of 76.00%in the control group,and the difference had extremely statistical significance(P<0.001).No adverse reactions were observed in the observation group and the control group during treatment.Conclusi

关 键 词：微生态制剂 哮喘 心理问题 认知功能 

分 类 号：R256.12[医药卫生—中医内科学] G479[医药卫生—中医学]