血清CXCL10、肾酶的水平变化与狼疮性肾炎病情活动的关系  

Relationship between changes of serum CXCL10 and renalase levels and disease activity of lupus nephritis

作　　者：陈珊珊[1] 刘东海[1] 岳英丽[1] CHEN Shan-shan;LIU Dong-hai;YUE Ying-li(Department of Nephrology,Langfang People's Hospital,Langfang Hebei 065000,China)

机构地区：[1]廊坊市人民医院肾内科,河北廊坊065000

出　　处：《临床和实验医学杂志》2022年第2期189-193,共5页Journal of Clinical and Experimental Medicine

基　　金：河北省卫健委科研课题(编号:2018013138)。

摘　　要：目的探讨狼疮性肾炎(LN)患者血清趋化因子配体10(CXCL10)、肾酶的变化及其意义。方法回顾性选取2016年4月至2018年12月在廊坊市人民医院确诊的LN患者87例(LN组)、慢性肾炎患者90例(对照组)。根据系统性红斑狼疮疾病活动度评分(SLEDAI-2000)将LN组分为活动组57例,非活动组30例;根据肾脏穿刺活检结果:Ⅲ型21例,Ⅳ型39例,Ⅴ型27例。检测LN组和对照组、不同疾病活动情况LN患者、不同LN分型LN患者的血清CXCL10、肾酶水平。结果LN组的血清CXCL10、肾酶测定值为(8.84±1.63)μg/L、(164.5±33.0)ng/mL,均高于对照组[(6.60±1.50)μg/L、(89.2±14.0)ng/mL],差异均有统计学意义(P<0.05)。活动期组LN患者的血清CXCL10、肾酶测定值为(9.30±1.61)μg/L、(175.5±30.6)ng/mL,显著高于非活动期组[(8.11±1.50)μg/L、(140.0±28.4)ng/mL],差异均有统计学意义(P<0.05)。Ⅳ型的LN患者血清CXCL10、肾酶水平为(9.41±1.52)μg/L、(177.7±26.7)ng/mL,显著高于Ⅲ型[(8.22±1.46)μg/L、(130.8±24.8)ng/mL]、Ⅴ型[(8.35±1.55)μg/L、(158.4±28.0)ng/mL],差异均有统计学意义(P<0.05)。LN患者血清CXCL10、肾酶测定值与SLEDAI-2000评分均呈显著的正相关(r=0.557、0.605,P<0.05)。结论LN患者血清CXCL10、肾酶水平显著的升高,并且与疾病活动程度关系密切。Objective To investigate the changes of serum chemokine ligand 10(CXCL10)and renalase in patients with lupus nephritis(LN)and their significance.Methods A total of 87 patients with LN(LN group)and 90 patients with chronic nephritis(control group)diagnosed in Langfang People's Hospital from April 2016 to December 2018 were selected retrospectively.According to the systemic lupus erythematosus disease activity score(SLEDAI-2000),the LN group was divided into 57 cases in the active group and 30 cases in the inactive group;according to the results of kidney biopsy:21 cases in typeⅢ,39 cases in typeⅣ,and 27 cases in type V.The levels of serum CXCL10 and renalase LN group and control group,LN patients with different disease activities,and LN patients with different LN types were tested.Results The levels of serum CXCL10 and renalase in the LN group were(8.84±1.63)μg/L and(164.5±33.0)ng/mL,which were higher than those in the control group[(6.60±1.50)μg/L,(89.2±14.0)ng/mL],the differences were statistically significant(P<0.05).The levels of serum CXCL10 and renalase of LN patients in the active phase group were(9.30±1.61)μg/L and(175.5±30.6)ng/mL,which were significantly higher than those in the inactive phase group[(8.11±1.50)μg/L,(140.0±28.4)ng/mL],the differences were statistically significant(P<0.05).The levels of serum CXCL10 and renalase in typeⅣLN patients were(9.41±1.52)μg/L and(177.7±26.7)ng/mL,which were significantly higher than typeⅢ[(8.22±1.46)μg/L,(130.8±24.8)ng/mL],typeⅤ[(8.35±1.55)μg/L,(158.4±28.0)ng/mL],the differences were statistically significant(P<0.05).The serum CXCL10 and renalase values of patients with lupus nephritis showed a significant positive correlation with SLEDAI-2000 scores(r=0.557,0.605,P<0.05).Conclusion Patients with lupus nephritis have significantly increased serum CXCL10 and renalase levels,and are closely related to disease activity.

关 键 词：狼疮性肾炎 趋化因子配体10 肾酶 

分 类 号：R593.242[医药卫生—内科学]