干扰素联合聚甲酚磺醛治疗高危型HPV33阳性的宫颈炎患者的临床疗效及对CER、TNF-α、TNF-β的影响  

Effect of interferon combined with polycresol sulfonal in the treatment of high-risk HPV33-positive cervicitis on CER,TNF-αand TNF-β

作　　者：蔡斌[1] 朱岩 王扣琴 赵乐 CAI Bin;ZHU Yan;WANG Kou-qin(Department of Gynaecology and Obstetrics,the First People's Affiliated Hospital of Shanghai Jiao Tong University,Shanghai 201620,China;Department of Gynaecology and Obstetrics,Jiading Branch of Shanghai First People's Hospital,Shanghai 201812,China)

机构地区：[1]上海交通大学附属第一人民医院妇产科,上海201620 [2]上海市第一人民医院嘉定分院妇产科,上海201812

出　　处：《临床和实验医学杂志》2022年第2期193-196,共4页Journal of Clinical and Experimental Medicine

基　　金：上海市科委项目(编号:164119502)。

摘　　要：目的观察干扰素联合聚甲酚磺醛治疗高危型人乳头瘤病毒33(HPV33)阳性的宫颈炎患者的临床疗效及对铜蓝蛋白(CER)、肿瘤坏死因子-α(TNF-α)、肿瘤坏死因子-β(TNF-β)的影响。方法回顾性选取2019年1月至2021年5月上海交通大学附属第一人民医院诊治的高危型HPV33阳性的宫颈炎患者110例,参照其治疗方案进行均分组,两组均给予微波治疗,对照组术后给予干扰素治疗,观察组术后在对照组基础上给予聚甲酚磺醛治疗。记录两组治疗效果、HPV感染转阴率、不良反应发生率,检测与比较治疗前、治疗后两组HPV病毒载量、CER、TNF-α、TNF-β、白介素家族[白细胞介素(IL)-2、IL-6、IL-17、IL-23]的差异。结果观察组总有效率为94.55%,高于对照组(81.82%),差异有统计学意义(P<0.05)。治疗后,两组患者血清CER、TNF-α、TNF-β、IL-2、IL-6、IL-17、IL-23水平较治疗前显著降低,且观察组CER、TNF-α、TNF-β、IL-2、IL-6、IL-17、IL-23水平为(121.52±15.34)U/L、(4.22±1.03)μg/L、(11.05±2.14)pg/mL、(8.45±0.91)pg/mL、(22.05±3.57)pg/mL、(18.45±4.02)pg/mL、(12.64±2.86)pg/mL,均低于对照组[(134.25±19.22)U/L、(7.14±1.52)μg/L、(15.63±3.85)pg/mL、(9.11±1.04)pg/mL、(29.52±4.15)pg/mL、(25.66±8.23)pg/mL、(16.89±4.11)pg/mL],差异均有统计学意义(P<0.05)。治疗后,两组患者HPV病毒载量较治疗前显著降低,且观察组HPV病毒载量为(0.85±0.31)×10^(5)拷贝/mL,均低于对照组[(1.32±0.57)×10^(5)拷贝/mL],差异均有统计学意义(P<0.05)。两组在HPV感染转阴率、不良反应发生率(阴道干涩感、低热、头痛)方面比较,差异均无统计学意义(P>0.05)。结论干扰素联合聚甲酚磺醛治疗高危型HPV33阳性的宫颈炎可促进HPV转阴,并提高临床疗效,其机制可能与抑制CER、TNF-α、TNF-β、白介素家族等相关因子的表达有关。Objective To observe the clinical efficacy of interferon combined with polycresol sulfonaldehyde in the treatment of patients with high-risk human papillomavirus 33(HPV33)positive cervicitis and the influence of ceruloplasmin(CER),tumor necrosis factor-α(TNF-α)and tumor necrosis factor-β(TNF-β).Methods A total of 110 patients with high-risk HPV33-positive cervicitis admitted to the First People's Affiliated Hospital of Shanghai Jiao Tong University from January 2019 to May 2021 were retrospectively selected and divided into groups according to their treatment plan.Both groups were given microwave therapy,and the control group was given interferon therapy after surgery.The observation group was treated with polycresol sulfonaldehyde on the basis of the control group after operation.The treatment effect,HPV infection rate,and adverse reaction rate of the two groups were recorded.Before and after treatment,the differences of HPV viral load,CER,TNF-α,TNF-β,interleukin family[interleukin(IL)-2,IL-6,IL-17,IL-23]were tested and compared.Results The total effective rate of the observation group was 94.55%,which was higher than that of the control group(81.82%),and the difference was statistically significant(P<0.05).After treatment,the levels of serum CER,TNF-α,TNF-β,IL-2,IL-6,IL-17,and IL-23 in the two groups were significantly lower than before treatment,and the levels of CER and TNF-α,TNF-β,IL-2,IL-6,IL-17,and IL-23 in the observation group were(121.52±15.34)U/L,(4.22±1.03)μg/L,(11.05±2.14)pg/mL,(8.45±0.91)pg/mL,(22.05±3.57)pg/mL,(18.45±4.02)pg/mL,(12.64±2.86)pg/mL,which were lower than those in the control group[(134.25±19.22)U/L,(7.14±1.52)μg/L,(15.63±3.85)pg/mL,(9.11±1.04)pg/mL,(29.52±4.15)pg/mL,(25.66±8.23)pg/mL,(16.89±4.11)pg/mL],the differences were statistically significant(P<0.05).After treatment,the HPV viral load of the two groups of patients was significantly lower than before treatment,and the HPV viral load of the observation group was(0.85±0.31)×10^(5) copies/mL,which was lowe

关 键 词：宫颈炎 干扰素 聚甲酚磺醛 高危型人乳头瘤病毒33 

分 类 号：R711.74[医药卫生—妇产科学]