巨幼细胞性贫血患者中CA-153的表达水平及其与Hb、LDH相关性  

Expression of CA-153 in Megaloblastic Anemia Patients and Its Correlation with Hb and LDH

作　　者：夏冬歌 权衡 牛紫光 XIA Dong-ge;QUAN Heng;NIU Zi-guang(Department of Laboratory Medicine,Shanghai General Hospital,Shanghai 200080,China)

机构地区：[1]上海市第一人民医院检验科,上海200080

出　　处：《临床和实验医学杂志》2022年第1期83-86,共4页Journal of Clinical and Experimental Medicine

基　　金：上海市自然科学基金面上项目(编号:21ZR1454900)。

摘　　要：目的探究糖类抗原153(CA-153)在巨幼细胞性贫血患者中的表达及其与血红蛋白(Hb)、乳酸脱氢酶(LDH)的相关性。方法前瞻性选择2015年5月至2019年5月上海市第一人民医院收治的81例巨幼细胞性贫血患者为病例组,同期体检健康者50例为对照组。检测并比较两组血清CA-153、Hb、LDH水平;采用Pearson相关分析巨幼细胞性贫血患者血清CA-153与Hb、LDH相关性;采用多元逐步回归分析CA-153的影响因素;采用受试者工作特征(ROC)曲线分析CA-153、Hb、LDH对巨幼细胞性贫血预测价值。结果病例组血清CA-153、LDH水平为(52.09±5.83) U/mL、(964.32±99.86) U/L,显著高于对照组[(19.36±4.71) U/mL、(186.12±48.77) U/L],血清Hb水平为(76.79±9.28) g/L,显著低于对照组[(118.60±11.52) g/L],差异均有统计学意义(P <0.05)。巨幼细胞性贫血患者血清CA-153水平与血清Hb水平呈负相关(r=-0.879,P <0.05),与血清LDH水平呈正相关(r=0.564,P <0.05)。以CA-153为因变量,Hb、LDH为自变量进行多元逐步回归分析,结果显示Hb、LDH是巨幼细胞性贫血患者血清CA-153水平的影响因素(P <0.05)。Hb对巨幼细胞性贫血预测价值明显优于CA-153(P <0.05),LDH对巨幼细胞性贫血预测价值明显优于Hb(P <0.05),CA-153、Hb、LDH联合检测对巨幼细胞性贫血预测价值明显优于各项指标单独检测(P <0.05)。结论 CA-153、LDH在巨幼细胞性贫血患者血清中呈高水平状态,Hb在巨幼细胞性贫血患者血清中呈低水平状态,巨幼细胞性贫血患者血清CA-153与Hb、LDH相关,CA-153联合Hb、LDH可共同预测巨幼细胞性贫血的发生。Objective To investigate the expression of cancer antigen 153( CA-153) in megaloblastic anemia patients and its correlation with hemoglobin( Hb) and lactate dehydrogenase( LDH). Methods Eighty-one patients with megaloblastic anemia( case group) and 50 healthy individuals( control group) in Shanghai General Hospital from May 2015 to May 2019 were prospectively selected. Serum CA-153,Hb,AND LDH levels were compared between groups. Pearson correlation analysis was used to analyze the correlation between serum CA-153 and Hb and LDH in patients with megaloblastic anemia. Multivariate stepwise regression analysis was used to analyze the influencing factors of CA-153.The receiver operating characteristic curve( ROC) was used to analyze the predictive value of CA-153,Hb,and LDH for megaloblastic anemia.Results The serum levels of CA-153 and LDH levels in the case group were( 52. 09 ± 5. 83) U/mL and( 964. 32 ± 99. 86) U/L,which were significantly higher than those in the control group [( 19. 36 ± 4. 71) U/mL,( 186. 12 ± 48. 77) U/L],the serum levels of Hb was( 76. 79 ± 9. 28)g/L,which was significantly lower than the control group [( 118. 60 ± 11. 52) g/L],the differences were statistically significant( P < 0. 05).Serum CA-153 levels in patients with megaloblastic anemia were negatively correlated with serum Hb levels( r =-0. 879,P < 0. 05),and positively correlated with serumLDH levels( r = 0. 564,P < 0. 05). Taking CA-153 as the dependent variable and Hb and LDH as independent variables,multivariate stepwise regression analysis showed that Hb and LDH were the influencing factors of serum CA-153 level in patients with megaloblastic anemia( P < 0. 05). The predictive value of Hb for megaloblastic anemia was significantly better than that of CA-153( P < 0. 05),and the predictive value of LDH for megaloblastic anemia was significantly better than Hb( P < 0. 05). The predictive value of combined detection of CA-153,Hb and LDH for megaloblastic anemia was better than that of the single detection( P < 0. 05). Conclusion

关 键 词：巨幼细胞性贫血 糖类抗原153 血红蛋白 乳酸脱氢酶 相关性 

分 类 号：R556[医药卫生—血液循环系统疾病]