外周血嗜酸性粒细胞计数与中老年人冠状动脉钙化的关系  

Relationship between peripheral blood eosinophil count and coronary artery calcification in middle-aged and elderly people

作　　者：程序 杨忖卿 石凤祥[2] 孙黎[2] 庞博[1] 谷春 侯雪筠[1] 费佳欣 刘贵建[1] CHENG Xu;YANG Cunqing;SHI Fengxiang;SUN Li;PANG Bo;GU Chun;HOU Xueyun;FEI Jiaxin;LIU Guijian(Department of Clinical Laboratory,Guang′anmen Hospital of China Academy of Chinese Medical Sciences,Beijing 100053,China;Department of Radiology,Guang′anmen Hospital of China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院检验科,北京100053 [2]中国中医科学院广安门医院放射科,北京100053

出　　处：《国际检验医学杂志》2022年第3期309-312,共4页International Journal of Laboratory Medicine

基　　金：中华国际科学交流基金会检验检测科技专项基金(Z2019LBJ003)。

摘　　要：目的探讨外周血嗜酸性粒细胞计数与中老年人冠状动脉钙化的关系。方法选取2021年2-5月就诊于本院、年龄>40岁并行CT冠状动脉造影的患者118例为研究对象,评估冠状动脉钙化评分(CACS)与外周血嗜酸粒细胞计数及主要心血管危险因素(包括年龄、吸烟状况、高血压、血脂异常、糖尿病)的关系。结果女性外周血嗜酸性粒细胞计数明显低于男性(P=0.001),糖尿病患者的外周血嗜酸性粒细胞计数明显高于非糖尿病患者(P=0.038)。高血压患者的log(CACS+1)明显高于无高血压患者(P=0.036),血脂异常患者log(CACS+1)明显高于血脂正常患者(P=0.019)。高嗜酸性粒细胞组的log(CACS+1)高于低嗜酸性粒细胞组(P=0.0147)。结论外周血嗜酸性粒细胞计数与中老年人冠状动脉钙化之间存在一定关系。Objective To investigate the relationship between peripheral blood eosinophil count and coronary artery calcification in middle-aged and elderly people.Methods A total of 118 patients who were admitted to our hospital from February to May 2021,more than 40 years old and underwent CT coronary angiography were selected as the research subjects.The relationship between coronary artery calcium score(CACS)and peripheral blood eosinophil count and major cardiovascular risk factors(including age,smoking status,hypertension,dyslipidemia,and diabetes mellitus)were evaluated.Results The peripheral blood eosinophil count in women was significantly lower than that in men(P=0.001),and the peripheral blood eosinophil count in diabetic patients was significantly higher than that in non-diabetic patients(P=0.038).The log(CACS+1)of patients with hypertension was significantly higher than that of patients without hypertension(P=0.036),and the log(CACS+1)of patients with dyslipidemia was significantly higher than that of patients with normal blood lipids(P=0.019).The log(CACS+1)of the high eosinophil group was higher than that of the low eosinophil group(P=0.0147).Conclusion There is a certain relationship between peripheral blood eosinophil count and coronary artery calcification in middle-aged and elderly people.

关 键 词：嗜酸性粒细胞 冠状动脉钙化 动脉粥样硬化 中老年人 

分 类 号：R543.3[医药卫生—心血管疾病]