香豆素衍生物荧光传感器对Zn^(2+)的识别及细胞成像  

Recognition and Cell Imaging of Zn^(2+) by Coumarin Derivative Fluorescence Sensor

作　　者：尹计秋 安永林[1] 贾献超[1] 焦扬 YIN Ji‑Qiu;AN Yong‑Lin;JIA Xian‑Chao;JIAO Yang(State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian,Liaoning 116024,China;College of Medical Laboratory,Dalian Medical University,Dalian,Liaoning 116044,China)

机构地区：[1]大连理工大学精细化工国家重点实验室,大连116024 [2]大连医科大学检验医学院,大连116044

出　　处：《无机化学学报》2022年第2期368-376,共9页Chinese Journal of Inorganic Chemistry

基　　金：大连市高层次人才创新支持计划(No.2019RQ039);中央高校基本科研业务费专项资金(No.DUT20LK12)资助。

摘　　要：制备了基于香豆素衍生物的荧光传感器CANQ,其可选择性地识别Zn^(2+)离子。通过NMR、MS、荧光光谱等技术研究了传感器的结构及荧光性能。传感器CANQ对Zn^(2+)离子具有显著的荧光增强响应,且响应速度快、选择性高、生物相容性好,可用于MCF‑7细胞中Zn^(2+)离子的成像。Coumarin‑derived fluorescence sensor was designed and synthesized to selectively recognize Zn^(2+)ions.The structure and fluorescence properties of the sensor were investigated by NMR,MS,fluorescence spectroscopy,and other technical methods.Sensor CANQ exhibited conspicuous fluorescent enhancement response to Zn^(2+)ion and had the characteristic of fast response,high selectivity,and good biocompatibility.It has been applied to the imaging of Zn^(2+)ions in MCF‑7 cells.

关 键 词：Zn^(2+)离子 香豆素衍生物 荧光传感器 识别 

分 类 号：O614.241[理学—无机化学]