从脾论治抑郁症临床疗效的Meta分析  

A Meta Analysis of Clinical Efficacy of Treating Depression from the Spleen

作　　者：于姚 郭蓉娟[2] 苟金 任非非 刘姝含 高维 YU Yao;GUO Rong-juan;GOU Jin;REN Fei-fei;LIU Shu-han;GAO Wei(Beijing Changping Hospital of Integrated Chinese and Western Medicine,Beijing,China,102208;Dongfang Hospital of Beijing University of Chinese Medicine,Beijing,China,102208;Beijing University of Chinese Medicine,Beijing,China,100029;Zhejiang Chinese Medicine University,Hangzhou,Zhejiang,China,310053;Yuquan Hospital of Tsinghua University,Beijing,China,100049)

机构地区：[1]北京市昌平区中西医结合医院,北京102208 [2]北京中医药大学东方医院,北京100078 [3]北京中医药大学,北京100029 [4]浙江中医药大学,浙江杭州310053 [5]清华大学玉泉医院,北京100049

出　　处：《河南中医》2022年第3期408-412,共5页Henan Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81874422,81573843);北京中医药大学优秀传承团队——王永炎名医传承工作室建设项目(1000062720028/010)。

摘　　要：目的:对从脾论治抑郁症的文献进行Meta分析,探讨其有效性和安全性。方法:检索中文期刊网全文数据库、万方科技信息数据库、中国生物医学文献数据库、中文维普科技期刊数据库、Cochrane library、PubMed、Embase数据库,收集自建库至2020年1月6日从脾论治抑郁症的随机对照试验,对符合纳入标准的文献运用Cochrane推荐的Review Manager 5.3软件进行Meta分析。结果:最终纳入8篇随机对照试验。试验组有效率显著高于对照组[OR=5.28,95%CI(2.77,10.07),P<0.01];汉密尔顿抑郁量表评分方面,两组比较差异无统计学意义[SMD=-1.22,95%CI(-2.49,0.05),P=0.06];不良反应发生率方面,试验组显著低于对照组[OR=0.10,95%CI(0.04,0.21),P<0.01]。结论:从脾论治联合抗抑郁西药治疗抑郁症疗效显著,且不良反应发生率低,但受纳入文献的数量和质量限制,今后仍需更多高质量、多中心、大样本的随机对照试验加以验证。Objective:To carry out a Meta analysis of the literature on the treatment of depression from the spleen,and to explore its effectiveness and safety.Methods:The Full-Text Database of Chinese Journal Network,Wanfang Science and Technology Information Database,Chinese Biomedical Literature Database,Chinese VIP Science and Technology Journal Database,Cochrane Library,PubMed and Embase Database were searched.The randomized controlled trials of treating the depression from the spleen from the establishment of the database to January 6,2020 were collected.The Review Manager 5.3 software recommended by Cochrane was used for the literature that met the inclusion criteria for Meta-analysis.Results:A total of 8 randomized controlled trials were finally included.The effective rate of the experimental group was significantly higher than that of the control group[OR=5.28,95%CI(2.77,10.07),P<0.01].In terms of Hamilton Depression Scale score,there was no significant difference between the two groups[SMD=-1.22,95%CI(-2.49,0.05),P=0.06].The incidence of adverse reactions in the experimental group was significantly lower than that in the control group[OR=0.10,95%CI(0.04,0.21),P<0.01].Conclusion:Treatment from the spleen combined with antidepressant Western medicine is effective in the treatment of depression,and the incidence of adverse reactions is low.However,due to the limitation of the quantity and quality of the included literature,more high-quality,multi center and large sample randomized controlled trials are still needed to verify in the future.

关 键 词：抑郁症 从脾论治 META分析 

分 类 号：R259.494[医药卫生—中西医结合]