E-Cad、G-17、HER-2与胃癌术后复发风险的相关性  

Correlation between E-Cad,G-17,HER-2 and postoperative recurrence risk of gastric cancer

作　　者：茆政 钱增堃 应斐 王昭俐 肖群 崔凡 MAO Zheng;QIAN Zengkun;YING Fei;WANG Zhaoli;XIAO Qun;CUI Fan(Department of Clinical Laboratory,Wuhu First People's Hospital,Wuhu 241000,Anhui,China)

机构地区：[1]芜湖市第一人民医院检验科,安徽芜湖241000

出　　处：《检验医学》2022年第1期41-46,共6页Laboratory Medicine

基　　金：芜湖市卫生健康委员会科研项目(WHWJ2021y018)。

摘　　要：目的探讨血清上皮型钙黏蛋白(E-Cad)、胃泌素-17(G-17)水平和肿瘤组织中人类表皮生长因子受体2(HER-2)表达与胃癌患者术后复发风险的相关性。方法选取行胃癌根治术治疗的胃癌患者92例,检测术前血清E-Cad、G-17水平和肿瘤组织HER-2的表达。对所有患者随访5年,以胃癌复发或随访满5年为随访终点。以胃良性病变患者92例作为对照组。收集所有胃癌患者的临床资料(性别、年龄、临床分期、分化程度、复发情况等)。采用受试者工作特征(ROC)曲线评估各项指标判断胃癌复发的效能。采用Cox回归分析评估影响胃癌患者复发的危险因素。采用Kaplan-Meier生存曲线评估胃癌患者的5年复发情况。结果胃癌组血清G-17水平和肿瘤组织HER-2阳性率均显著高于对照组(P=0.000),血清E-Cad水平显著低于对照组(P=0.000)。血清E-Cad、G-17水平及肿瘤组织HER-2阳性率与胃癌的TNM分期、分化情况及是否复发有关(P<0.05),与性别无关(P>0.05)。ROC曲线分析结果显示,E-Cad、G-17、HER-2单项检测与联合检测判断胃癌复发的曲线下面积(AUC)分别为0.775、0.822、0.603、0.950。Kaplan-Meier生存曲线分析结果显示,胃癌复发患者E-Cad低表达组复发率高于高表达组(P<0.05),而G-17低表达组、HER-2低表达组复发率低于G-17高表达组、HER-2高表达组(P<0.05)。Cox回归分析结果显示,E-Cad水平降低、G-17水平升高、HER-2表达升高均是胃癌复发的危险因素[风险比(HR)分别为0.835、1.568、3.981,95%可信区间(CI)分别为0.767~0.909、1.292~1.904、1.504~10.538]。结论E-Cad、G-17、HER-2在预测胃癌患者根治术后复发中均有重要价值。Objective To investigate the correlation between serum epithelial cadherin(E-Cad)and gastrin-17(G-17)levels and human epidermal growth factor receptor-2(HER-2)expression in tumor tissues and the risk of postoperative recurrence in patients with gastric cancer.Methods Totally,92 patients with gastric cancer who underwent radical gastric cancer treatment were enrolled,and the serum E-Cad and G-17 levels and the tumor tissue HER-2 expression were determined before the operation.All the patients were followed up for 5 years,with gastric cancer recurrence or 5 years of follow-up as the follow-up endpoint.Totally,92 patients with benign gastric lesions were enrolled as control group.The clinical data(sex,age,clinical stage,degree of differentiation,recurrence and so on)of all the gastric cancer patients were collected.Receiver operating characteristic(ROC)curve was used to evaluate the efficiency of various indicators in judging the recurrence of gastric cancer.Cox regression analysis was used to evaluate the risk factors affecting the recurrence of gastric cancer.Kaplan-Meier survival curve was used to evaluate the 5-year recurrence of gastric cancer.Results The serum G-17 level and the positive rate of HER-2 in gastric cancer group were higher than those in control group(P=0.000),and the serum E-Cad level was lower than that in control group(P=0.000).The levels of serum E-Cad and G-17 and the positive rate of HER-2 were correlated with TNM stage,differentiation and recurrence of gastric cancer(P<0.05),but there was no correlation with sex(P>0.05).ROC curve analysis showed that the areas under curves(AUC)of single determinations of E-Cad,G-17 and HER-2 and combined determination were 0.775,0.822,0.603 and 0.950,respectively.KaplanMeier survival curve analysis showed that the recurrence rate of low expression of E-Cad was higher than that of high expression group(P<0.05),while the recurrence rate of low expression of G-17 and low expression of HER-2 was lower than that of high expression of G-17 and high expression of

关 键 词：上皮型钙黏蛋白 胃泌素-17 人类表皮生长因子受体2 胃癌 复发 

分 类 号：R446.1[医药卫生—诊断学]