Regulation of megakaryopoiesis by bone marrow macrophage polarization  

作　　者：Ming Hou 

机构地区：[1]Qilu Hospital of Shandong University,Cheeloo College of Medicine,Shandong University,Jinan,Shandong,China

出　　处：《Blood Science》2021年第4期149-150,共2页血液科学（英文）

摘　　要：Immune thrombocytopenia(ITP)is an autoimmune disorder characterized by increased bleeding tendency and thrombocytopenia.The main mechanisms include the loss of immune tolerance,accelerated platelet destruction,impaired bone marrow(BM)microenvironment,and decreased platelet production.1–5 The processes of megakaryocytopoiesis and thrombocytopoiesis occur within a complex BM microenvironment.Macrophages(MFs)are crucial regulators of normal hematopoiesis in the BM microenvironment,whereas very few studies focus on the effect of BM MFs on megakaryopoiesis,especially the MF polarization subsets in thrombocytopenic disease.Prolonged thrombocytopenia(PT)after hematopoietic stem cell transplantation is a strong risk factor for transplantation-related morbidity and mortality,and no standard treatment guideline exists.Meanwhile,PT,characterized by dysfunctional megakaryocyte(MK)maturation and thrombocytopenia,not only provides a paradigm for understanding the relationship between MK development and BM microenvironment but also an ideal disease model for studying thrombocytopenia。

关 键 词：IMPAIRED MORTALITY MARROW 

分 类 号：R55[医药卫生—血液循环系统疾病]