血清PCT、IL-6、内毒素联合检测诊断老年呼吸道细菌性感染的临床价值  

Clinical value of combined detection of serum PCT,IL-6 and endotoxin in the diagnosis of respiratory tract bacterial infection in the elderly

作　　者：王海宁 孙巨军 白香妮 王阿蕾 李欣 WANG Haining;SUN Jujun;BAI Xiangni;WANG Alei;LI Xin(Clinical Laboratory Department,Xi'an XD Group Hospital,Xi'an 710077,China)

机构地区：[1]西电集团医院检验科,陕西西安710077

出　　处：《临床医学研究与实践》2022年第1期118-121,共4页Clinical Research and Practice

摘　　要：目的探究血清降钙素原(PCT)、白细胞介素-6(IL-6)、内毒素联合检测诊断老年呼吸道细菌性感染的临床价值。方法选择2019年10月至2020年10月我院收治的240例老年呼吸道感染患者作为研究对象,经胸部X线检查及实验室细菌学检测结果将患者分为细菌感染组和非细菌性感染组,各120例;选择同期在我院进行常规体检的60例健康体检者作为健康组。比较三组研究对象的血清PCT、IL-6、内毒素水平;分析血清PCT、IL-6、内毒素单独检测和联合检测对老年呼吸道细菌性感染的诊断结果及效能。结果细菌感染组的血清PCT、IL-6、内毒素水平显著高于非细菌感染组和健康组,差异具有统计学意义(P<0.05)。经血清PCT、IL-6、内毒素单独检测确诊为细菌性感染的患者分别为112、113、107例,联合检测确诊129例。血清PCT、IL-6、内毒素联合检测对老年呼吸道细菌性感染的诊断灵敏度、准确度及阴性预测值均显著高于其单独检测(P<0.05)。结论老年呼吸道细菌性感染患者血清PCT、IL-6、内毒素水平变化显著,能够与非细菌性感染进行有效的鉴别,且联合检测的灵敏度及准确度更高,对指导合理应用抗生素具有非常重要的意义。Objective To explore the clinical value of combined detection of serum procalcitonin(PCT),interleukin-6(IL-6) and endotoxin in the diagnosis of respiratory tract bacterial infection in the elderly.Methods A total of 240 elderly patients with respiratory tract infection admitted in our hospital from October 2019 to October 2020 were selected as the research objects,and the patients were divided into bacterial infection group and non-bacterial infection group by chest X-ray examination and laboratory bacteriological detection results,with 120 cases in each group;60 healthy physical examination persons who underwent routine physical examination in our hospital at the same period were selected as health group.The levels of serum PCT,IL-6 and endotoxin of research objects in the three groups were compared;the diagnostic results and efficacy of single and combined detection of serum PCT,IL-6 and endotoxin for respiratory tract bacterial infection in the elderly were analyzed.Results The levels of serum PCT,IL-6 and endotoxin in the bacterial infection group were significantly higher than those in the non-bacterial infection group and the healthy group,the differences were statistically significant(P<0.05).There were 112,113 and 107 patients diagnosed as bacterial infections by single detection of serum PCT,IL-6,and endotoxin,respectively,and 129 cases were confirmed by combined detection.The diagnostic sensitivity,accuracy and negative predictive value of combined detection of serum PCT,IL-6 and endotoxin for respiratory tract bacterial infection in the elderly were significantly higher than those of single detection(P<0.05).Conclusion The levels of serum PCT,IL-6 and endotoxin in elderly patients with respiratory tract bacterial infection change significantly,it can be effectively distinguished from non-bacterial infection,and the combined detection has higher sensitivity and accuracy,which is of great significance to guide the rational application of antibiotics.

关 键 词：降钙素原 白细胞介素-6 内毒素 老年呼吸道细菌性感染 抗生素 非细菌性感染 

分 类 号：R373.1[医药卫生—病原生物学]