冠心舒通胶囊联合瑞替普酶溶栓治疗急性ST段抬高型心肌梗死的效果  

Effect of Guanxin Shutong capsule combined with reteplase thrombolysis in the treatment of acute ST-segment elevation myocardial infarction

作　　者：李晓妮 牛颖[2] LI Xiaoni;NIU Ying(People's Hospital of Huyi District,Xi'an 710300;Sanyuan County Hospital,Xianyang 713800,China)

机构地区：[1]鄠邑区人民医院,陕西西安710300 [2]三原县医院,陕西咸阳713800

出　　处：《临床医学研究与实践》2022年第1期158-161,共4页Clinical Research and Practice

摘　　要：目的观察冠心舒通胶囊联合瑞替普酶溶栓治疗急性ST段抬高型心肌梗死(ASTEMI)的效果。方法选取2018年7月至2020年8月我院收治的120例ASTEMI患者开展回顾性研究,根据治疗方式不同将其分为对照组(60例,瑞替普酶溶栓)和研究组(60例,对照组基础上联合冠心舒通胶囊)。比较两组患者的血管再通情况、心电图情况、血小板活化功能指标、血脂代谢指标及主要不良心血管事件(MACE)发生情况。结果研究组的血管再通、TIMI 3级血流及ST段回落>70%患者占比均显著高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的ST段偏移、Q波时、Q波/R波比较,差异无统计学意义(P>0.05);治疗后,两组的ST段偏移、Q波时、Q波/R波均显著降低,且研究组显著低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的CD63、CD62p、MPA水平比较,差异无统计学意义(P>0.05);治疗后,两组的CD63、CD62p、MPA水平均显著降低,且研究组显著低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的TG、TC、LDL-C水平比较,差异无统计学意义(P>0.05);治疗后,两组的TG、TC、LDL-C水平均显著降低,且研究组显著低于对照组,差异具有统计学意义(P<0.05)。研究组的MACE总发生率为11.67%,显著低于对照组的30.00%,差异具有统计学意义(P<0.05)。结论冠心舒通胶囊联合瑞替普酶溶栓治疗ASTEMI的效果显著,可显著提高血管再通率,改善患者的心电图、血脂代谢和血小板活化功能,降低MACE发生率,值得临床推广应用。Objective To observe the effect of Guanxin Shutong capsule combined with reteplase thrombolysis in the treatment of acute ST-segment elevation myocardial infarction(ASTEMI).Methods A total of 120 patients with ASTEMI treated in our hospital from July 2018 to August 2020 were selected for retrospective study.The patients were divided into control group(60 cases,reteplase thrombolysis) and study group(60 cases,combined with Guanxin Shutong capsule on the basis of the control group) according to different treatment methods.The vascular recanalization,ECG,platelet activation function indexes,blood lipid metabolism indexes and major adverse cardiovascular events(MACE) were compared between the two groups.Results The proportion of patients with vascular recanalization,TIMI grade 3 blood flow and ST segment fall rate >70% in the study group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in ST segment offset,Q wave time and Q wave/R wave between the two groups(P>0.05);after treatment,ST segment offset,Q wave time and Q wave/R wave in the two groups significantly decreased,and those in the study group were significantly lower than the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of CD63,CD62 p and MPA between the two groups(P>0.05);after treatment,the levels of CD63,CD62 p and MPA in the two groups significantly decreased,and those in the study group were significantly lower than the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of TG,TC and LDL-C between the two groups(P >0.05);after treatment,the levels of TG,TC and LDL-C in the two groups significantly decreased,and those in the study group were significantly lower than the control group,and the differences were statistically significant(P<0.05).The total i

关 键 词：冠心舒通胶囊 瑞替普酶 溶栓治疗 急性ST段抬高型心肌梗死 

分 类 号：R259[医药卫生—中西医结合]