Interaction between xylanase and a proton pump inhibitor on broiler chicken performance and gut function  

作　　者：Gemma Gonzalez-Ortiz Sophie A.Lee Kirsi Vienola Kari Raatikainen German Jurgens Juha Apajalahti Michael R.Bedford 

机构地区：[1]AB Vista,Marlborough,Wiltshire,SN84AN,United Kingdom [2]Alimetrics Ltd.,Koskelontie 19 B,Espoo,Finland

出　　处：《Animal Nutrition》2022年第1期277-288,共12页动物营养（英文版）

基　　金：This research was financially supported by AB Vista.The authors wish to thank the Physiology Professor Dra.Patri Vergara,from the Veterinary School of the Universitat Autonoma de Barcelona(Spain)for the technical advice in the selection of the best model to apply in chickens at the beginning of the project.

摘　　要：Three hundred thirty-six Ross 308 male broiler chicks were used in a 21-d study to explore performance and gut function when treated with a proton pump inhibitor(PPI;0 or 89 mg/kg)in a 2×2 factorial arrangement with a xylanase(Xyl;0 or 0.1 g/kg)to determine if the beneficial activity of arabinoxylan(AX)depolymerisation,through arabinoxylo-oligosaccharides(AXOS)production,starts in the upper gastrointestinal tract.Treatment with the PPI started from d 14,and by d 21 animal performance had deteriorated(P<0.001).An interaction was observed between PPI and Xyl for feed conversion ratio(FCR)(P<0.05),whereby the combination reduced the negative effect of PPI on FCR.Application of PPI raised digesta pH in the gizzard and caecum(P<0.05),increased protein concentrations in the lower gut(P<0.05)and reduced intake of digestible nutrients(P<0.05).Caecal concentrations of indole,p-cresol,ammonia and the ratio of total volatile fatty acid(VFA)to butyric acid were increased with PPI(P<0.05),indicating enhanced protein fermentation.Xylanase activity in the digesta were greatest in the caeca,especially when Xyl was supplemented(P<0.001).The concentration of total soluble AX was greater in the gizzard and ileal digesta with Xyl supplementation(P<0.05),supporting the depolymerisation action of xylanase even under acidic conditions.These data suggest xylanase may function in the gizzard even though pH is not optimal for activity and emphasises the importance of chlorohydric acid secretions in ensuring overall optimum gut function.AX depolymerisation benefits animal performance although it is still unknown how the AXOS produced with xylanase supplementation in the upper gastrointestinal tract influence the microbial populations and overall gut functionality.

关 键 词：XYLANASE Proton pump inhibitor Arabinoxylan degradation Protein fermentation Broiler chicken 

分 类 号：S831.5[农业科学—畜牧学]