A bifunctional MXene-modified scaffold for photothermal therapy and maxillofacial tissue regeneration  

作　　者：Fengji Li Yanling Yan Yanan Wang Yaru Fan Huiru Zou Han Liu Rui Luo Ruixin Li Hao Liu 

机构地区：[1]Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction,Tianjin Stomatological Hospital,The Affiliated Stomatological Hospital of Nankai University,Tianjin 300041,China [2]Tianjin Medical University,Tianjin 300041,China [3]Department of Stomatology,Shenzhen Luohu Hospital of Traditional Chinese Medicine,Shenzhen Hospital of Shanghai University of Traditional Chinese Medicine,Shenzhen 518001,China

出　　处：《Regenerative Biomaterials》2021年第6期148-158,共11页再生生物材料（英文版）

基　　金：supported by the Tianjin Science and Technology Project(19ZXDBSY00070);the National Natural Science Foundation of China(11972198);the Special Project of Tianjin Clinical Medicine Key Discipline(HWZX001).

摘　　要：Oral squamous cell carcinoma is one of the most common malignant tumours in the oral and maxillofacial regions and is highly malignant and prone to recur despite the development of various effective treatments,including surgery and chemoradiotherapy.Actually,it is difficult to ensure the complete elimination of tumour cells,and maxillofacial bone defects caused by surgery are hard to heal by themselves.In addition,chemoradiotherapy can bring serious side-effects.Therefore,it is imperative to develop a postoperative therapy to kill residual squamous cancer cells and repair bone defects without any side-effects.Here,we prepared a 3D scaffold by a 3D printing technique and freeze-drying method,which contained collagen,silk and hydroxyapatite(CSH)and was functionalized with MXene nanosheets(M-CSH).The considerable photothermal effect with long-term stability can significantly kill squamous CAL-27 cancer cells in vitro and inhibit tumour growth in vivo,increasing the probability of the M-CSH scaffold being applied in the photothermal therapy of oral squamous cell carcinoma.Moreover,the cell proliferation-and osteogenic-related protein expression of mouse embryonic osteogenic precursors(MC3T3-E1)indicated excellent biocompatibility and osteogenic activity of M-CSH scaffolds.The good compression modulus(52.8362.25 kPa)and in vivo bone formation performance made it possible to be used as reconstructive materials for bone defects.This scaffold is likely promising in future tissue engineering,especially for the multifunctional treatment of maxillofacial tumours.

关 键 词：OSCC MXene 3D printing photothermal therapy bone formation 

分 类 号：R318[医药卫生—生物医学工程]