干扰素治疗手足口病的用药策略  

Medication Strategy of Interferon in the Treatment of Hand, Foot and Mouth Disease

作　　者：邓慧玲[1] 张玉凤[2] DENG Huiling;ZHANG Yufeng(Xi'an Central Hospital,Xi'an 710003,China;Xi'an Children's Hospital,Xi'an 710003,China)

机构地区：[1]西安市中心医院,陕西西安710003 [2]西安市儿童医院,陕西西安710003

出　　处：《皮肤科学通报》2021年第6期552-556,共5页Dermatology Bulletin

摘　　要：手足口病主要由柯萨奇病毒A16(CoxA16)、肠道病毒71型(EV71)等肠道病毒感染引起,其中重症手足口病多由EV71感染引起。目前临床中对于手足口病并无特效药,通常采用对症、抗病毒等方法进行治疗。其中干扰素为儿科常用药物,主要通过促进抗病毒蛋白(AVP)的表达和提高机体细胞免疫达到抗病毒效果。干扰素α-1b、干扰素α-2b为临床中常用的干扰素药物剂型,本文对干扰素治疗手足口病的用药策略进行综述,以期为手足口病患儿的临床治疗提供参考。Hand-foot-mouth disease(HFMD) is mainly caused by enterovirus infections such as coxsackie virus A16(CoxA16) and enterovirus 71(EV71), among which severe HFMD is mostly caused by EV71 virus.At present, there is no specific medicine for HFMD in clinical practice, and it is usually treated with symptomatic treatment and antiviral treatment.Interferon is a commonly used drug in pediatrics, which achieves antiviral effects mainly by promoting the expression of antiviral protein(AVP) and the body′s cellular immunity.Interferon α-1 b and interferon α-2 b are commonly used types of interferon drugs in clinical practice.This article reviews the medication strategies of interferon in the treatment of HFMD to provide references for the clinical treatment of children with HFMD.

关 键 词：干扰素 手足口病 抗病毒蛋白 免疫功能 

分 类 号：R979.5[医药卫生—药品] R725.1[医药卫生—药学]