异噁唑啉酮的不对称芳基化反应  

Enantioselective Arylation of Isoxazolones with Quinone Monoimines

作　　者：张家燕 黄敏 张晓梅[1] ZHANG Jia-yan;HUANG Min;ZHANG Xiao-mei(Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu 610041,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院成都有机化学研究所,四川成都610064 [2]中国科学院大学,北京100049

出　　处：《合成化学》2022年第1期47-57,共11页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21672208)。

摘　　要：在手性磷酸的作用下,实现了异噁唑啉酮和对苯醌单亚胺的不对称芳基化反应,以高收率和高对映选择性构建了4-芳基异噁唑啉酮衍生物。对其中一个产物进行单晶培养,确定了绝对构型。A highly enantioselective arylation of isoxazolones with quinone monoimines has been established under a chiral phosphoric acid.A range of arylation products containing an all-carbon quaternary stereocenter were prepared with good yields and moderate to good enantioselectives.The absolute configuration of a product was unambiguously confirmed by single-crystal X-ray diffraction.

关 键 词：手性磷酸 异噁唑啉酮 对苯醌单亚胺 不对称芳基化 合成 绝对构型 

分 类 号：O62[理学—有机化学]