系统性免疫炎症指数对老年心房颤动患者预后价值的研究  

Prognostic value of systemic immune-inflammation index in elderly AF patients

作　　者：王越[1] 郑汝杰 袁明月 段洁莹 张金盈[1] Wang Yue;Zheng Rujie;Yuan Mingyue;Duan Jieying;Zhang Jinying(Department of Cardiology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan Province,China)

机构地区：[1]郑州大学第一附属医院心血管内科,450000

出　　处：《中华老年心脑血管病杂志》2022年第2期136-139,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨系统性免疫炎症指数(SII)与老年心房颤动(房颤)患者不良预后的关系。方法选择老年房颤患者1768例,根据SII最佳截断值分为低SII组1091例(<451.01)和高SII组677例(≥451.01)。收集并记录入院时的人口统计学特征、检验结果和超声心动图。通过电话等方式对患者进行随访。中位随访时间22.5个月,记录主要终点全因死亡和心源性死亡,次要终点缺血性脑卒中。结果高SII组全因死亡和心源性死亡比例明显高于低SII组(14.3%vs 5.3%,P<0.01;9.3%vs 3.8%,P<0.01)。调整混杂因素后,多变量Cox回归分析显示,高SII组全因死亡和心源性死亡风险明显增加(HR=1.776,95%CI:1.109~3.065,P=0.018;HR=1.512,95%CI:1.011~3.742,P=0.025)。与低SII组比较,高SII组全因死亡和心源性死亡累积发生风险显著增加(P;<0.01)。结论 SII水平与老年房颤患者不良预后相关,是老年房颤患者死亡发生的独立预测因素。Objective To study the association between systemic immune-inflammation index(SII) and poor outcome in elderly atrial fibrillation(AF) patients.Methods A total of 1768 elderly AF patients were divided into low SII(<451.01) group(n=1091) and high SII(≥451.01) group(n=677) according to the optimal cut-off value of SII.Their demographic characteristics, laboratory testing and echocardiography parameters were recorded on admission.The patients were followed up for 22.5 months by telephone, during which the primary endpoints(all-cause death and cardiogenic death) and secondary endpoint(ischemic stroke) were recorded.Results The incidence of all-cause death and cardiogenic death was significantly higher in high SII group than in low SII group(14.3% vs 5.3%,P<0.01;9.3% vs 3.8%,P<0.01).The risk of all-cause death and cardiogenic death increased significantly in high SII group after adjustment of potential confounding factors(HR=1.776,95%CI:1.109-3.065,P=0.018;HR=1.512,95%CI:1.011-3.742,P=0.025),and was significantly higher in high SII group than in low SII group(P;<0.01).Conclusion SII is closely associated with the poor outcome and is an independent predictor for the mortality in elderly AF patients.

关 键 词：炎症 心房颤动 死亡率 淋巴细胞 血小板计数 

分 类 号：R541.75[医药卫生—心血管疾病]