脂蛋白相关磷脂酶A2和心型脂肪酸结合蛋白诊断急性心肌梗死的价值及与预后的关系  

Value of Lp-PLA2 and H-FABP for diagnosing AMI and its relationship with MACE in AMI patients

作　　者：方顺淼[1] 葛兴利 李运田[2] 杜大勇[2] Fang Shunmiao;Ge Xingli;Li Yuntian;Du Dayong(Department of Cardiology,Xi'an First Hospital or First Affiliated Hospital of Northwest University,Xi'an 710002,Shaanxi Province,China)

机构地区：[1]西安市第一医院西北大学附属第一医院心内科,710002 [2]解放军305医院心内科

出　　处：《中华老年心脑血管病杂志》2022年第2期148-150,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：陕西省重点研发计划(2018SF-127)。

摘　　要：目的探讨血浆脂蛋白相关磷脂酶A2(Lp-PLA2)和心型脂肪酸结合蛋白(H-FABP)对老年急性心肌梗死(AMI)患者的诊断价值及与主要不良心血管事件(MACE)的相关性。方法选取西安市第一医院的120例AMI患者为观察组,同期住院的非冠心病患者60例为对照组。采用ELISA法测血浆Lp-PLA2和H-FABP水平,随访12个月,记录MACE,用logistic回归模型分析。结果观察组术前血浆Lp-PLA2、H-FABP水平高于术后和对照组(P<0.01),观察组术后高于对照组(P<0.05)。观察组MACE发生率明显高于对照组(17.50%vs 0%,P<0.01)。logistic回归分析显示,术前、术后Lp-PLA2和H-FABP是MACE的独立预测因子(P<0.05,P<0.01),且上述指标均与MACE呈显著正相关(P<0.05,P<0.01)。结论 Lp-PLA2和H-FABP反映心肌损伤及炎性反应程度,对老年AMI有较高的诊断价值,并对MACE有较好的预测价值。Objective To A2 (Lp-PLA2)study the value of lipoprotein-associated phospholipase protein(H-FABP)for and heart-type fatty acid binding diagnosing AMI and its relationship with observa-patients.Methods One AMI MACE in group hundred and twenty AMI patients served as an tion PLA2and60CHD-free patients served as a control group in this study.Their serum Lpfor and H-FABP levels were incidence measured by ELISA.The patients were followed up and12their months,during which the MACE of MACE was recorded.The risk facors for AMI reanalysis.Results lationship with serum in AMI patients were analyzed by logistic regression higher The PCI Lp-PLA2and H-FABP levels were significantly in observation group before PCI(P<0.01)and after than in control group group were significantly higher in observation group higher PCI(P<0.05).The after than in control incidence of MACE was significantly in analysis independin vs0,P<0.01).Logistic group(17.50%observation group than in control and regression levels showed that preoperative postoperative serum Lp-PLA2and H-FABP were MACE MACE(P<0.05,P<0.01)and of ent predictors were positively related with show AMI pamyocarvalue tients(P<0.05,P<0.01).Conclusion Lp-PLA2and H-FABP can value the severity of high dial injury and inflammatory reactions with a high diagnostic for AMI and a for predicting MACE in AMI patients.

关 键 词：1-烷基-2-乙酰甘油磷酸胆碱酯酶 脂肪酸结合蛋白质类 心肌梗死 酶联免疫吸附测定 预后 

分 类 号：R542.22[医药卫生—心血管疾病]