黄体期促排卵方案的临床应用进展  

Progress in clinical application of luteal-phase ovulation stimulation

作　　者：周焕宇 王莹 石玉华 Huanyu Zhou;Ying Wang;Yuhua Shi(Qingdao Women and Children's Hospital,Qingdao 266011,China;Reproductive Hospital Affiliated to Shandong University,Shandong University,Jinan 250001,China)

机构地区：[1]青岛妇女儿童医院,266011 [2]山东大学附属生殖医院,济南250001

出　　处：《中华生殖与避孕杂志》2021年第12期1134-1138,共5页Chinese Journal of Reproduction and Contraception

基　　金：国家重点研发计划项目(2021YFC2700404,2018YFC1003202);泰山学者工程专项经费(ts201712103)。

摘　　要：卵泡波理论的提出和胚胎冷冻技术的进步,使得黄体期促排卵方案得以应用。这一方案应用于不同卵巢功能的人群所获得的助孕结局不尽相同,对于卵巢储备功能低下、卵巢低反应和紧急生育力保存人群,该方案可打破月经周期的限制,有效控制早发黄体生成素峰,相较于卵泡期促排卵可能会获得更多具有正常发育潜能的卵子和胚胎。双刺激方案可在短时间内获得更多可用的卵子及胚胎,从而改善时间敏感性患者的助孕结局。作为超促排卵方案的一种,黄体期促排卵的结局受卵泡期处理、促排卵启动时机和用药方案影响,本文将从以上方面对黄体期促排卵的影响进行综述。The luteal-phase ovarian stimulation protocol has benefited from the proposal of follicular waves theory and the improvement of embryo cryopreservation technology.The effect of luteal-phase protocol on pregnancy outcome varies among women with different ovarian functions.For women with diminished ovarian reserve(DOR),poor ovarian response(POR)or fertility preservation requirements,this protocol could break the limitation of menstrual cycle,and effectively control the premature luteinizing hormone(LH)peak which provides a chance to obtain more eligible eggs and embryos compared with the follicular-phase protocol.Double stimulation may obtain more eligible eggs and embryos within a short period,which could improve the pregnancy outcomes of the time-sensitivity patients.As one of controlled ovarian hyperstimulation regimens,the outcome of luteal-phase ovulation stimulation is influenced by follicular-phase management,the timing of ovarian stimulation and medication regimen.Therefore,this article will finish the overview about the influences of aforesaid factors to the luteal-phase ovulation stimulation.

关 键 词：卵泡波 卵巢刺激 黄体期 双刺激方案 卵巢反应低下 

分 类 号：R714.8[医药卫生—妇产科学]