假单胞菌属双组分信号转导系统调控吩嗪生物合成研究进展  

Research progress on phenazine biosynthesis regulated by two-component signal transduction system of Pseudomonas aeruginosa

作　　者：邱薇 刘磊[1,2] 康杰 叶泽铭 葛菁萍 QIU Wei;LIU Lei;KANG Jie;YE Zeming;GE Jingping(Engineering Research Center of Agricultural Microbiology Technology,Ministry of Education,Heilongjiang University,Harbin 150500,Heilongjiang,China;Key Laboratory of Microbiology,College of Heilongjiang Province,School of Life Sciences,Heilongjiang University,Harbin 150080,Heilongjiang,China)

机构地区：[1]黑龙江大学农业微生物技术教育工程研究中心,黑龙江哈尔滨150500 [2]黑龙江大学生命科学学院微生物省高校重点实验室,黑龙江哈尔滨150080

出　　处：《微生物学通报》2022年第1期352-362,共11页Microbiology China

基　　金：黑龙江省自然科学基金重点项目(ZD2020C008)。

摘　　要：吩嗪是由假单胞菌或链霉菌产生的一类具有抗菌、抗肿瘤和抗寄生虫活性的含氮杂环代谢物,在农业和医疗领域具有广泛的应用。但吩嗪的合成受到复杂的级联网络调控。本文总结了假单胞菌属中双组分信号转导系统(two-component signal transduction system,TCS)对吩嗪生物合成的调控机制,阐明在双组分信号转导系统的控制下小RNA(small RNA)和群体感应(quorum sensing)对吩嗪生物合成的影响,为假单胞菌属调控吩嗪合成级联网络的进一步研究提供参考。Phenazine is a class of nitrogen-containing heterocyclic compounds.It is usually a secondary metabolite produced by Pseudomonas or Streptomyces.Phenazine has antibacterial activity,and phenazine also has anti-insect and anti-tumor activity.It is not only widely used in agriculture,but also widely used in medical field.But the synthesis of phenazine is very complex,because it is regulated by a multi-cascade network.In this article,the author will summarize the regulatory mechanism of two-component signal transduction system on phenazine biosynthesis in Pseudomonas.This paper elucidates the effect of small RNA on phenazine biosynthesis under the control of each two-component signal transduction system,and the effect of quorum sensing on phenazine biosynthesis under the control of each two-component signal transduction system.The purpose of this study is to provide a reference for the further study of the cascade network of phenazine synthesis regulated by Pseudomonas.

关 键 词：假单胞菌属 吩嗪 双组分信号转导系统 群体感应 小RNA 

分 类 号：O626[理学—有机化学]