桥本氏甲状腺炎患者食物特异性IgG抗体水平关系的研究分析  

Study on the relationship between food specific IgG antibody and Hashimoto's thyroiditis

作　　者：安赤颖 卢东晖[2] 孔行锋 李欣 卢长红 温丽安 冯丽珠 卢盼盼 Chiying An;Donghui Lu;Xingfeng Kong;Xin Li;Changhong Lu;Lian Wen;Lizhu Feng;Panpan Lu(Endocrinology department Shenzhen Hengsheng Hospital,Shenzhen 518102,China;Endocrinology department Peking University Shenzhen Hospital,Shenzhen 518036,China;Clinical Laboratory department Shenzhen Hengsheng Hospital,Shenzhen 518102,China)

机构地区：[1]深圳恒生医院内分泌科,广东深圳518102 [2]北京大学深圳医院内分泌科,广东深圳518036 [3]深圳恒生医院检验科,广东深圳518102

出　　处：《国际免疫学杂志》2021年第6期626-630,共5页International Journal of Immunology

摘　　要：目的探索桥本氏甲状腺炎患者与食物不耐受之间的关系,为临床治疗提供参考。方法观察分析2020年4月至2021年5月在深圳恒生医院诊断桥本氏甲状腺患者(153例)食物不耐受的发生情况,采用条带免疫印迹法检测桥本氏甲状腺炎患者食物特异性免疫球蛋白(immunoglobulin,Ig)G抗体(共14项)的表达情况。结果在纳入的153名桥本氏甲状腺炎患者中,食物特异性IgG抗体检测总阳性率高达64.05%(98/153),其中对鸡蛋食物不耐受的发生率高达52.29%(80/153),其次是牛奶22.22%(34/153)。分层分析发现不同年龄段的食物不耐受总体发生率差异无统计学意义(χ^(2)=0.3868,P=0.5340),相对于≤30岁组,>30岁组的患者对鸡蛋、牛奶(χ^(2)值分别为4.1727和16.0912,P值均<0.05)的食物不耐受发生率均有所下降。结论桥本氏甲状腺炎患者普遍存在食物不耐受,且食物不耐受的发生率和性别无关,但随着年龄增加,对牛奶、鸡蛋等食物的不耐受发生率明显下降。Objective To explore the relationship between patients with Hashimoto’s thyroiditis and food intolerance,and to provide references for clinical treatment.Methods The occurrence of food intolerance in patients with Hashimoto's thyroiditis(153 cases)were observed and analyzed from April 2020 to May 2021 in Shenzhen Hengsheng Hospital.The results of food-specific(immunogloblin Ig)G antibodies(14 items)in patients with Hashimoto's thyroiditis were detected by strip immunoblotting.Results The total positive rate of food-specific IgG antibody in 153 patients with Hashimoto's thyroiditis was 64.05%(98/153).Among them,the incidence of egg food intolerance was 52.29%(80/153),followed by milk 22.22%(34/153).Stratified analysis showed that there was no significant difference in the overall incidence of food intolerance among different age groups(χ^(2)=0.3868,P=0.5340),compared with the≤30-year-old group,the incidence of food intolerance to eggs and milk were significantly decreased in the>30-year-old group(χ^(2) were 4.1727 and 16.0917,both P values<0.05).Conclusion Food intolerance is common in patients with Hashimoto's thyroiditis,and the incidence of food intolerance has no relationship with gender.However,with the increase of age,the incidence of intolerance to food such as milk and eggs decreases significantly.

关 键 词：桥本氏甲状腺炎 食物不耐受 食物特异性免疫球蛋白G抗体 肠道微生物 

分 类 号：R581.4[医药卫生—内分泌]